RECRUITINGOBSERVATIONAL

Antiphospholipid Syndrome and Postpartum Pulmonary Artery Pressure

Association Between Preeclampsia, Antiphospholipid Syndrome and Postpartum Pulmonary Artery Pressure, Systemic Arterial Pressure and Cardiovascular Function.

About This Trial

The primary goal of this observational study is to learn about postpartum pulmonary artery pressure in women who suffered from Preeclampsia and Antiphospholipid Syndrome. The main question it aims to answer is whether the conjunction of preeclampsia with obstetric antiphospholipid syndrome significantly foster the development of long-lasting pulmonary hypertension. Only participants who suffered from preeclampsia during pregnancy will be followed for a period up to 3 years postpartum. Researchers will compare women with or without obstetric antiphospholipid syndrome.

Who May Be Eligible (Plain English)

Who May Qualify: - Age: \> 16 years. - Consent or waiver of consent according Chapter 9 - Preeclampsia Defined as: • New onset hypertension (blood pressure \>140/90mmHg on multiple occasions after 20 weeks of gestation) In combination with new onset of 1 or more of the following: - Proteinuria (urine protein \>300mg /24h or 2+ or higher in dipstick on multiple occasions) - Platelet count \<100,000/microL, - Serum creatinine \>97.2 micromol/L, - Liver transaminases at least twice the upper limit of the normal concentrations, - Pulmonary edema, - New-onset and persistent headache, - Visual symptoms. -Postnatal follow up at the obstetrical and cardiology clinic, Inselspital Bern, Switzerland. Who Should NOT Join This Trial: - Age: \< 16 years - Incomplete or ambiguous data: if data confirming the eligibility criteria or data to analyze the primary endpoint is not fully available or despite efforts assessed as significantly ambiguous, the data set will be excluded from analyses, since no analysis is possible Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Age: \> 16 years. * Consent or waiver of consent according Chapter 9 * Preeclampsia Defined as: • New onset hypertension (blood pressure \>140/90mmHg on multiple occasions after 20 weeks of gestation) In combination with new onset of 1 or more of the following: * Proteinuria (urine protein \>300mg /24h or 2+ or higher in dipstick on multiple occasions) * Platelet count \<100,000/microL, * Serum creatinine \>97.2 micromol/L, * Liver transaminases at least twice the upper limit of the normal concentrations, * Pulmonary edema, * New-onset and persistent headache, * Visual symptoms. -Postnatal follow up at the obstetrical and cardiology clinic, Inselspital Bern, Switzerland. Exclusion Criteria: * Age: \< 16 years * Incomplete or ambiguous data: if data confirming the eligibility criteria or data to analyze the primary endpoint is not fully available or despite efforts assessed as significantly ambiguous, the data set will be excluded from analyses, since no analysis is possible

Treatments Being Tested

DIAGNOSTIC_TEST

Echocardiography images

Transthoracic echocardiographic (Vivid E95) performed in all included patients between three months and three years after delivery. * Left ventricular ejection fraction, * Left ventricular mass index, * Septal and lateral mitral annular E-wave velocity assessed by tissue Doppler, * Tricuspid annular plane systolic excursion, * Left atrial volume index, * Right ventricle to right atrium (RV/RA) gradient

DIAGNOSTIC_TEST

24-hour ambulatory blood pressure monitoring

Twenty-four-hour ABPM performed between three months and three years after delivery using validated recorders (Spacelabs model 90217, USA)

Locations (1)

Inselspital

Bern, Switzerland