Netherlands Cohort Study on Acute HIV Infection

Who May Qualify: - Written willing to sign a consent form to store samples and perform genetic testing. - Separate written willing to sign a consent form for invasive sampling procedures: leukapheresis, sigmoidoscopy with biopsies, lymph node excision biopsy and lumbar puncture, with storage of samples. - Age \>= 18 years - An acute HIV-1 infection, defined according to the Fiebig stages I-IV (acute infection), as described in the previous paragraph (HIV-1 RNA positive and 4th generation ELISA negative or HIV-1 RNA positive and 4th generation HIV ELISA positive with indeterminate Western Blot). Patients in Fiebig stage V and VI (recent infection) will only be included if they have a documented negative HIV test 6 months prior to the positive test or if they are in Fiebig stage V with a p31 negative blot - Female subjects should be willing to use adequate contraception. Who Should NOT Join This Trial: - Contraindication for proposed cART regimen (e.g. impaired renal function). - Mental disorder that in the view of the investigator would interfere with adherence to the treatment or the study procedures, or the decision to participate in the study. - Immunosuppressive medication or other diseases associated with weakened immune system. Always talk to your doctor about whether this trial is right for you.