Effects of the Contraceptive Implant in Women With Sickle Cell Disease

Who May Qualify: - Female aged 18-45 - Diagnosis of sickle cell disease (SS or SB0) - Report of at least 1 vaso-occlusive pain episode per month on average in the previous 6 months - Willing to discontinue any hormonal contraception at the time of enrollment. waiting period after previous treatment of 1 month required for all hormonal contraception prior to enrollment in the study. - Access to a device with text messaging capability - Must be able to read and understand English - Willing to comply with study procedures Who Should NOT Join This Trial: - SC Disease - Use of Depo Provera in the past 6 months - Changes to sickle cell medications in the past 3 months - Contraindications to use of Nexplanon device as per clinical standards - Currently pregnant or pregnant within the last month or seeking to become pregnant - Currently breastfeeding Always talk to your doctor about whether this trial is right for you.