Adaptive Treatment for Acute Myeloid Leukemia Based on D14 MRD Results

Who May Qualify: - Known and written willing to sign a consent form voluntarily - Age ≥ 18 years - Newly diagnosed AML patients (per WHO 2022 classification criteria for AML diagnosis), who are not suitable for intensive chemotherapy: - 75 years or Aged 18 to 74 years with at least one of the following comorbidities: Eastern Cooperative Oncology Group (ECOG) performance status score of 2 or 3 or 4; Cardiac history of Congestive Heart Failure (CHF) requiring treatment or Ejection Fraction \<= 50% or chronic stable angina; Diffusing capacity of the Lung for Carbon Monoxide (DLCO) \<= 65% or Forced Expiratory Volume in 1 second (FEV1) \<= 65%; Creatinine clearance \>= 30 mL/min to \< 45 ml/min; Moderate hepatic impairment with total bilirubin \> 1.5 to \<= 3.0 × Upper Limit of Normal (ULN); Any other comorbidity that the physician judges to be incompatible with intensive chemotherapy . - Liver function meets the following criteria: aspartate aminotransferase (AST) ≤ 3.0×ULN\*; alanine aminotransferase (ALT) ≤3.0×ULN\*; Bilirubin≤1.5×ULN\*; For subjects \<75 years old, the bilirubin level can be ≤3.0×ULN; Unless due to leukemic organ involvement. - Renal function meets the following criteria: kidney function (creatinine clearance) at least 30 mL/min (Cockroft-Gault formula) - Life expectancy ≥ 4 weeks Who Should NOT Join This Trial: - History of any malignancies prior to study entry with exception noted in the protocol. - Participant has known HIV infection, active hepatitis B virus (HBV) and/or hepatitis C virus (HCV) . - Participant has known active central nervous system (CNS) involvement with AML. - Must not have received prior anti-AML treatment except for hydroxyurea Always talk to your doctor about whether this trial is right for you.