RECRUITINGPhase 1 / Phase 2INTERVENTIONAL
Curcumin and Retinal Study
Curcumin and Retinal Amyloid-beta Pilot Study
About This Trial
To test how two weeks of curcumin supplementation would cross the blood brain barrier (BBB) and attach to amyloid beta proteins, to assess the feasibility (safety and bioavailability), and to explore the resulting abundance/composition of gut microbiota.
Who May Be Eligible (Plain English)
Inclusion:
- Both male and female, age 40 - 89 years.
- Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent session, we will use this diagnosis/documentation for eligibility criteria. Otherwise, the ophthalmic exam will be repeated after consent is obtained for the study.
- No pre-existing liver or kidney diseases by self-report.
Exclusion:
- Patients with ocular diseases (macular degeneration, severe diabetes retinopathy)
- Had used systemic antibiotics within 1 month prior to the start of the study intervention
- Had taken any turmeric or curcumin products within 2 weeks prior to the start of the study intervention
- Had a known allergy to black pepper
- Women that are pregnant or breastfeeding
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion:
* Both male and female, age 40 - 89 years.
* Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent session, we will use this diagnosis/documentation for eligibility criteria. Otherwise, the ophthalmic exam will be repeated after consent is obtained for the study.
* No pre-existing liver or kidney diseases by self-report.
Exclusion:
* Patients with ocular diseases (macular degeneration, severe diabetes retinopathy)
* Had used systemic antibiotics within 1 month prior to the start of the study intervention
* Had taken any turmeric or curcumin products within 2 weeks prior to the start of the study intervention
* Had a known allergy to black pepper
* Women that are pregnant or breastfeeding
Treatments Being Tested
DRUG
Low curcumin group
One curcumin capsule (250 mg curcumin) after each meal, 3 times a day for 2 weeks.
DRUG
High curcumin group
One curcumin capsule (500 mg curcumin) after each meal, 3 times a day for 2 weeks.
Locations (1)
Texas Tech University Health Sciences Center
Lubbock, Texas, United States