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RECRUITINGPhase 1 / Phase 2INTERVENTIONAL

Curcumin and Retinal Study

Curcumin and Retinal Amyloid-beta Pilot Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

To test how two weeks of curcumin supplementation would cross the blood brain barrier (BBB) and attach to amyloid beta proteins, to assess the feasibility (safety and bioavailability), and to explore the resulting abundance/composition of gut microbiota.

Who May Be Eligible (Plain English)

Inclusion: - Both male and female, age 40 - 89 years. - Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent session, we will use this diagnosis/documentation for eligibility criteria. Otherwise, the ophthalmic exam will be repeated after consent is obtained for the study. - No pre-existing liver or kidney diseases by self-report. Exclusion: - Patients with ocular diseases (macular degeneration, severe diabetes retinopathy) - Had used systemic antibiotics within 1 month prior to the start of the study intervention - Had taken any turmeric or curcumin products within 2 weeks prior to the start of the study intervention - Had a known allergy to black pepper - Women that are pregnant or breastfeeding Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion: * Both male and female, age 40 - 89 years. * Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent session, we will use this diagnosis/documentation for eligibility criteria. Otherwise, the ophthalmic exam will be repeated after consent is obtained for the study. * No pre-existing liver or kidney diseases by self-report. Exclusion: * Patients with ocular diseases (macular degeneration, severe diabetes retinopathy) * Had used systemic antibiotics within 1 month prior to the start of the study intervention * Had taken any turmeric or curcumin products within 2 weeks prior to the start of the study intervention * Had a known allergy to black pepper * Women that are pregnant or breastfeeding

Treatments Being Tested

DRUG

Low curcumin group

One curcumin capsule (250 mg curcumin) after each meal, 3 times a day for 2 weeks.

DRUG

High curcumin group

One curcumin capsule (500 mg curcumin) after each meal, 3 times a day for 2 weeks.

Locations (1)

Texas Tech University Health Sciences Center
Lubbock, Texas, United States