V+PSF-M for Tobacco Cessation in HIV Care in India

Who May Qualify: - Adults (≥18 years) - Confirmed HIV diagnosis - Self-reported current smoking or dual tobacco use verified either by exhaled carbon monoxide ≥7 ppm, or by positive qualitative cotinine point-of-care test - Able to read at 6th grade level or greater and speak Tamil, Telugu or English - Able to use varenicline safely based on evaluation by primary provider at VHS - Women of childbearing potential who consent to use a medically approved method of contraception or abstain from intercourse while taking study medication and for one month after. - Ready to quit or interested in quitting Who Should NOT Join This Trial: - Pregnant or planning to become pregnant in the next 6 months - Breastfeeding - Myocardial infarction in past 30 days or unstable angina - History of liver or kidney failure - Alanine aminotransferase and Aspartate aminotransferase \> 2 times upper limit of normal or creatinine clearance \<50 in past 6 months - History of suicide attempt - Current suicidal ideation - Untreated or unstable major depressive disorder - History of psychosis or on anti-psychotic medications - Cognitive impairment limiting ability to consent - Allergy to varenicline Always talk to your doctor about whether this trial is right for you.