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RECRUITINGINTERVENTIONAL

The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE

The Prevalence, Risk Factors and Optimal Biopsy Protocol of Barrett's Esophagus in Taiwan - A Prospective Randomized Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Detections of goblet cells and dysplasia are crucial for diagnosis and determining the surveillance program of Barrett's esophagus (BE). However, the optimal biopsy numbers and their yield rates of intestinal metaplasia (IM) and dysplasia are still uncertain, especially in Asia. The aim of this study was to determine the optimal biopsy protocol of BE.

Who May Be Eligible (Plain English)

Who May Qualify: - Adults with columnar-lined esophagus Who Should NOT Join This Trial: - A prior history of endoscopic treatment for Barrett's Esophagus - A prior history of upper gastrointestinal malignancy - A prior history of total or subtotal gastrectomy - Esophageal varices noted during the procedure - Uncontrolled coagulopathy - Taking antiplatelet drug or anticoagulant Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Adults with columnar-lined esophagus Exclusion Criteria: * A prior history of endoscopic treatment for Barrett's Esophagus * A prior history of upper gastrointestinal malignancy * A prior history of total or subtotal gastrectomy * Esophageal varices noted during the procedure * Uncontrolled coagulopathy * Taking antiplatelet drug or anticoagulant

Treatments Being Tested

PROCEDURE

One biopsy

To do one biopsy at the proximal part of the longest columnar-lined esophagus.

PROCEDURE

Three biopsy

To do three biopsy at the proximal, middle and distal part of the longest columnar-lined esophagus.

PROCEDURE

Seattle protocol

To do 4-quadrant biopsy every 1-2 cm at the esophagogastric junction. Seattle protocol has been considered as the gold standard biopsy protocol for patients with suspected Barrett's Esophagus.

DEVICE

Endoscopy

The participants will receive meticulous endoscopic examination with narrow-band imaging.

Locations (1)

E-DA Hospital
Kaohsiung City, Taiwan