Skip to main content
TTrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor.
RECRUITINGOBSERVATIONAL

Investigating Neural Biomarkers for Gait in Parkinson's Patients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This observational study's main goal is to learn more about the neural mechanisms during movement in Parkinson's disease. Furthermore, it aims to inspire personalised treatment options. Participants will undergo a protocol that involves walking and gait-related motor tasks, such as seated stepping. During the protocol, brain activity will be recorded.

Who May Be Eligible (Plain English)

Who May Qualify: All participants - must have given willing to sign a consent form as documented by signature - agree to comply with the study procedures Healthy control group - no neurological, orthopedic, or rheumatologic disease history - no identified sensory impairment. - no epilepsy and self-diagnosed acute or chronic psychiatric disorders Parkinson's Patients - non-tremor dominant idiopathic PD patients - presence of postural instability (UPDRS \>1 for postural instability \[17\]), gait disturbance, and absence of other causes of reduced balance - Implanted with Percept™ PC neurostimulator - Able to be in the stimulation OFF Who Should NOT Join This Trial: - Relevant cognitive impairment, with a score on Montréal Cognitive Assessment (MoCA) \< 20 - History of physical or neurological condition that interferes with study procedures - Social and/or personal circumstances interfering with the ability to come to the session Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: All participants * must have given informed consent as documented by signature * agree to comply with the study procedures Healthy control group * no neurological, orthopedic, or rheumatologic disease history * no identified sensory impairment. * no epilepsy and self-diagnosed acute or chronic psychiatric disorders Parkinson's Patients * non-tremor dominant idiopathic PD patients * presence of postural instability (UPDRS \>1 for postural instability \[17\]), gait disturbance, and absence of other causes of reduced balance * Implanted with Percept™ PC neurostimulator * Able to be in the stimulation OFF Exclusion Criteria: * Relevant cognitive impairment, with a score on Montréal Cognitive Assessment (MoCA) \< 20 * History of physical or neurological condition that interferes with study procedures * Social and/or personal circumstances interfering with the ability to come to the session

Treatments Being Tested

DIAGNOSTIC_TEST

Neural Activity Recording

Neural Activity is measured using EEG in all groups. Additionally, in Parkinson's patients, local-field-potentials from deep brain stimulation electrodes are recorded.

DIAGNOSTIC_TEST

Movement Parameter Recording

Gait-related movement parameters are non-invasively recorded using motion capture, accelerometers and electromyography.

OTHER

Neuromodulation

Neural signals are recorded with the electrodes of the deep brain stimulation device. Parkinson's patients are asked to modulate their neural activity by observing the streamed neural activity and applying mental strategies.

Locations (1)

Cereneo
Vitznau, Canton of Lucerne, Switzerland