A Phase III Study of Oral Sudapyridine (WX-081) Tablets in Rifampicin-Resistant Pulmonary Tuberculosis Patients

Who May Qualify: - • Body mass index (BMI) and body weight of subjects: 15.0≤BMI≤28.0 kg/m2, and 40kg≤ body weight ≤90kg; - For clinically diagnosed patients with tuberculosis whose drug sensitivity test has proved to be at least resistant to rifampicin, phenotypic or molecular drug sensitivity test results within 3 months before the subject signs willing to sign a consent form can be accepted; - Direct sputum smear positive for acid-fast bacilli (AFB at least 1+); - Willing to discontinue all previous anti-tuberculosis drugs and accept a 7-day waiting period after previous treatment; - Non-lactating and pregnant women who agree to use contraception throughout the treatment; Or the male patient's spouse agrees to use contraception throughout the treatment. Who Should NOT Join This Trial: - • Allergic to any study drug or its ingredients; - A history of alcohol dependence or drug abuse; - With hematogenous disseminated pulmonary tuberculosis or extrapulmonary tuberculosis; - Drug susceptibility test before screening showed resistance to more than 4 of the 8 antituberculosis drugs in this study; - Have taken Bedaquiline before; - HIV-positive patients; - Laboratory obvious abnormalities; - A history of pointy torsion ventricular tachycardia or cardiac risk factors for pointy torsion ventricular tachycardia; - Repeated QTcF intervals \> 450ms; Clinically significant ventricular arrhythmias that may require medical or surgical treatment; - Documented cardiovascular diseases; - Peripheral neuropathy CTCAE grade 3 or grade 4; Grade 1 or grade 2 neuropathy that the investigator believes is likely to progress/worsen over the course of the study; optic neuritis; - Any serious cardiovascular, kidney, liver, blood, tumor, endocrine and metabolic, autoimmune or rheumatic diseases. Always talk to your doctor about whether this trial is right for you.