InheriteD brEast caNcer iTalian regIsTrY A Retrospective-prospective Observational Cohort Study to Evaluate Cancer Prevention Strategies in Women With a Deleterious Mutation in BRCA1-2

Who May Qualify: Cohort A (Retrospective): 1. Female sex 2. Age ≥ 18 years 3. Signed willing to sign a consent form 4. Documented germline deleterious mutation in BRCA1 and/or BRCA2 in people with: i) No history of cancer ii) Radically treated breast cancer iii) Stage IV breast cancer diagnosed after BRCA1-2 mutation detection 5. Admission to the participating Center since 1st of January 2010, prior to site activation Cohort B (Prospective): 1. Female sex 2. Age ≥ 18 years 3. Signed willing to sign a consent form 4. Documented germline deleterious mutation in BRCA1 and/or BRCA2 in people with: i) No history of cancer ii) Radically treated breast cancer iii) Stage IV breast cancer diagnosed after BRCA1-2 mutation detection 5. Admission to the participating Center after site activation Who Should NOT Join This Trial: Cohort A/B (Retrospective/Prospective): 1\. Other malignancies diagnosed within five years prior to BRCA1-2 mutation detection, except for: - ovarian cancer stage I-II - basal or squamous cell carcinoma of the skin - melanoma in situ - CIS of the cervix Always talk to your doctor about whether this trial is right for you.