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RECRUITINGINTERVENTIONAL

Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH

Safety of Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Burr Hole Craniostomy With Drainage for Chronic Subdural Hematoma

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

A prospective, multicenter, randomized controlled trial is designed to evaluate the safety of nerve block anesthesia combined with sedative anesthesia versus general anesthesia during burr hole craniostomy with drainage for chronic subdural hematoma.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients with chronic subdural hematoma with preoperative neurological dysfunction for burr hole drainage; - Age beween 18 to 80 - Chronic subdural hematoma verified on cranial computed tomography or magnetic resonance imaging with hematoma thickness \>1.0cm or midline shift \>1.0 cm. - Written willing to sign a consent form obtained Who Should NOT Join This Trial: - Preoperative unconsciousness (Glasgow Coma Scale\<13, or Markwalder Grade 2-4) or cognitive dysfunction (Mini-Cog≤3, or MMSE≤20) - Preoperative sensory or motor aphasia - Recurrence of hematoma with previous surgery for chronic subdural hematoma. - Previous intracranial surgery or with intracranial lesion - with severe comorbidity or other organ dysfunction - Allergic to anesthetics - Severe coagulopathy or high risk of life-threatening bleeding - Participating in another research Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients with chronic subdural hematoma with preoperative neurological dysfunction for burr hole drainage; * Age beween 18 to 80 * Chronic subdural hematoma verified on cranial computed tomography or magnetic resonance imaging with hematoma thickness \>1.0cm or midline shift \>1.0 cm. * Written informed consent obtained Exclusion Criteria: * Preoperative unconsciousness (Glasgow Coma Scale\<13, or Markwalder Grade 2-4) or cognitive dysfunction (Mini-Cog≤3, or MMSE≤20) * Preoperative sensory or motor aphasia * Recurrence of hematoma with previous surgery for chronic subdural hematoma. * Previous intracranial surgery or with intracranial lesion * with severe comorbidity or other organ dysfunction * Allergic to anesthetics * Severe coagulopathy or high risk of life-threatening bleeding * Participating in another research

Treatments Being Tested

PROCEDURE

Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia

Patients in the nerve block anesthesia combined with sedative anesthesia group will first receive cranial nerve blocks under standard monitoring. At the same time, intravenous dexmedetomidine infusion is started for sedation at a rate of 2-4ug/kg for 10 minutes, followed by a continuous infusion of 0.5-1ug/kg/h until the Richmond Agitation-Sedation Scale (RASS) of -3.

PROCEDURE

General Anesthesia

Patients will be induced with propofol or etomidate, sufentanil , rocuronium or cisatracurium .

Locations (1)

Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China