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RECRUITINGINTERVENTIONAL

CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)

CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain )

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this study is to determine if rapid outpatient evaluation vs hospitalization management is the best strategy (based on patient-centered measures and safe, equitable, and efficient resource use) for evaluating patients with acute chest pain who are at moderate risk for acute coronary syndrome (ACS). Patients will be randomized in the Emergency Department to either an outpatient evaluation (CARE-CP) or hospitalization evaluation for their symptoms.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥21 years old - Chest pain or Symptoms of acute coronary syndrome (ACS) - Moderate risk of ACS (all of the below) - Hear Score 4-6 - Non-Ischemic electrocardiogram (ECG) - Two Troponin measures \< Sex-Specific Upper Reference Limit - Women \<15 pg/ml - Men \<20 pg/ml - No prior coronary artery disease (CAD) - No Prior Myocardial Infarction (MI) - No Prior Coronary Revascularization Procedures - No Patients with ≥ 70% Obstructive Coronary Disease Who Should NOT Join This Trial: - ST Elevation Myocardial Infarction (STEMI) Activation - ST Changes or new T-wave inversions ≥1mm on ECG - Any Elevated Troponin Measure (Based on Sex-Specific 99th Percentile) - Serial change between Troponin Measures (Delta) ≥5 pg/mL - Stress Echocardiography, Nuclear Stress Test, Stress ECG, Stress Cardiac MRI, Coronary CT Angiogram (CCTA), Invasive Coronary Angiography (Cardiac Cath) within 1 year - "Clean" CCTA or Cardiac Cath (0% stenosis in all vessels) within the past 2 years - Chest Trauma - Pregnancy - Life Expectancy \< 1 year - Other comorbid conditions requiring hospitalization - Unstable Vitals (Blood Pressure \<90, Heart Rate \>120 or \<50, O2 Sat \<90%) - End Stage Renal Disease; Dialysis or estimated glomerular filtration rate (eGFR) \<30 mL/min - Transfers From Another Hospital - Non-English Speaking - Prisoners - Prior Enrollment - Already Enrolled in Other Interventional Trial Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age ≥21 years old * Chest pain or Symptoms of acute coronary syndrome (ACS) * Moderate risk of ACS (all of the below) * Hear Score 4-6 * Non-Ischemic electrocardiogram (ECG) * Two Troponin measures \< Sex-Specific Upper Reference Limit * Women \<15 pg/ml * Men \<20 pg/ml * No prior coronary artery disease (CAD) * No Prior Myocardial Infarction (MI) * No Prior Coronary Revascularization Procedures * No Patients with ≥ 70% Obstructive Coronary Disease Exclusion Criteria: * ST Elevation Myocardial Infarction (STEMI) Activation * ST Changes or new T-wave inversions ≥1mm on ECG * Any Elevated Troponin Measure (Based on Sex-Specific 99th Percentile) * Serial change between Troponin Measures (Delta) ≥5 pg/mL * Stress Echocardiography, Nuclear Stress Test, Stress ECG, Stress Cardiac MRI, Coronary CT Angiogram (CCTA), Invasive Coronary Angiography (Cardiac Cath) within 1 year * "Clean" CCTA or Cardiac Cath (0% stenosis in all vessels) within the past 2 years * Chest Trauma * Pregnancy * Life Expectancy \< 1 year * Other comorbid conditions requiring hospitalization * Unstable Vitals (Blood Pressure \<90, Heart Rate \>120 or \<50, O2 Sat \<90%) * End Stage Renal Disease; Dialysis or estimated glomerular filtration rate (eGFR) \<30 mL/min * Transfers From Another Hospital * Non-English Speaking * Prisoners * Prior Enrollment * Already Enrolled in Other Interventional Trial

Treatments Being Tested

BEHAVIORAL

Outpatient Evaluation

Subjects will receive an outpatient evaluation within 72 of being discharged from the ED.

BEHAVIORAL

Hospitalization Evaluation

Patients randomized to this arm receive evaluation for their symptoms in a hospital ward, observation unit, or emergency department boarding.

Locations (3)

Henry Ford Hospital
Detroit, Michigan, United States
Carolinas Medical Center
Charlotte, North Carolina, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States