Study of the Glymphatic System in Migraine

Who May Qualify: For patients: • Diagnosis of migraine, by the ICHD-3 criteria; For both patients and healthy controls: - Age between 18 and 60 years; - Willing and able to comply with scheduled visits. Exclusion criteria For patients: - Overuse of acute medications for headache; - Continuous or daily headache; - Other primary headache disorders, with the exception of infrequent tension-type headache. For healthy controls: • Any subject with frequent tension type headache, migraine, cluster headache, other pain syndromes or neurological conditions. For both patients and healthy controls: - Allergy to nitroglycerin; - Major psychiatric disorders such as bipolar affective disorder and schizophrenia; - Cardiovascular diseases that contraindicated the use of nitroglycerin; - Intracranial hypertension; - Cerebral haemorrhage; - Cerebral trauma; - Pulmonary toxic oedema; - Closed angle glaucoma; - Anaemia; - Pregnancy and breastfeeding; - Aortic stenosis or significant hypotension (SBP\<90mmHg or \<100mmHg and symptomatic) precluding nitroglycerin administration; - Use of sildenafil; - Any person unable to lie still within the environment of the MRI scanner for the required period to perform the study; - Any person where MRI scanning is contraindicated (metal implants, pacemaker, claustrophobia, etc.); - Use of illicit drugs; - MRI head showing any brain pathology, such as space-occupying lesions; - Any person unable to understand and follow the instructions of the investigators. Always talk to your doctor about whether this trial is right for you.