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RECRUITINGINTERVENTIONAL

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases- AiD GLIO Pilot Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This pilot study investigates whether advanced diffusion-weighted MRI (ADW-MRI) can differentiate between true tumor progression (TP) and a pseudoprogression (PsP) in patients with glioblastoma (GBM) or brain metastases.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients with histopathologically proven glioblastoma or brain metastasis and suspected tumor progress on standard MRI after first line therapy and who are candidates for elective surgical resection. - Able to give willing to sign a consent form Who Should NOT Join This Trial: - Contraindications to MRI (e.g. claustrophobia, pacemaker or other implants without MRI-approval, pregnancy) - Patients in a life-threatening condition - Patients in need of emergent surgery - Histopathological analyses of insufficient quality - Unable to give willing to sign a consent form - Age \<18 Years Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients with histopathologically proven glioblastoma or brain metastasis and suspected tumor progress on standard MRI after first line therapy and who are candidates for elective surgical resection. * Able to give informed consent Exclusion Criteria: * Contraindications to MRI (e.g. claustrophobia, pacemaker or other implants without MRI-approval, pregnancy) * Patients in a life-threatening condition * Patients in need of emergent surgery * Histopathological analyses of insufficient quality * Unable to give informed consent * Age \<18 Years

Treatments Being Tested

DIAGNOSTIC_TEST

Advanced diffusion-weighted MRI (ADW-MRI)

An advanced diffusion weighted MRI-sequence will be performed in addition to the routine MRI-diagnostics. This will require the patient to be scanned for additional 30 minutes in a separate MRI-scanner. This technique offers the opportunity of higher sensitivity towards subtle tissue changes associated with increased specificity relating to damage of different tissue components of the CNS. In the case of surgical resection, the histopathological findings will be correlated to the findings of the ADW-MRI.

Locations (1)

University Hospital Basel
Basel, Switzerland