Short-term Fat Overfeeding on the Effects of Liver Metabolism

Who May Qualify: - The participant is willing and able to give willing to sign a consent form for participation in the study. - Male or Female, aged ≥18 or ≤65 years. - Body Mass Index ≥19 ≤35 kg/m2 - No medical condition or relevant drug therapy that is known to affect liver or adipose tissue metabolism. - Weight stable for the previous 3 months Who Should NOT Join This Trial: - The participant is unwilling or unable to give willing to sign a consent form for participation in the study. - Aged ≤18 or ≥65 years - Body Mass Index ≤19 or ≥35kg/m2 - Blood haemoglobin \<135mg/dL for men and \<120mg/dL for women - Donated (or lost) ≥250 ml of blood in the previous two months. - On a weight loss diet or have decreased their body weight by \>5% in the previous 3 months. - Have increased their body weight by \>5% in the previous 3 months. - Any metabolic condition or relevant drug therapy - Current smoker - History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women) - Haemorrhagic disorders - Anticoagulant treatment - History of albumin allergy - Pregnant or nursing mothers - Women prescribed any contraceptive agent or device including oral contraceptives, hormone replacement therapy (HRT) or who have used these within the last 12 months History of severe claustrophobia - Presence of metallic implants, pacemakers, or are unwilling to remove any piercings - History of an eating disorder or any other psychological condition that may affect the participant's ability to adhere to study intervention/experimental diets. Always talk to your doctor about whether this trial is right for you.