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RECRUITINGINTERVENTIONAL

Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of the study is to determine whether the use of the CEST sequence would have diagnostic performance equivalent to the reference method of T2\* infusion with contrast injection in the diagnosis of radionecrosis of lung cancer brain metastases.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients \> 18 years of age - Histologically proven primary lung cancer - Histologically proven or not brain metastases - Irradiated metastases - Inclusion in a treatment protocol for brain metastases by brain metastasis in toto or stereotactic or gamma-knife radiotherapy - Morphological increase of one or more lesions of secondary brain metastases on a follow-up MRI - Patients affiliated to a social security scheme Who Should NOT Join This Trial: - Opposition to the study - Contraindication to MRI - Refusal of imaging by the patient - Patient with state medical aid (unless exemption from affiliation) - Severe cognitive impairment making willing to sign a consent form impossible - Patients under guardianship or deprived of liberty Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients \> 18 years of age * Histologically proven primary lung cancer * Histologically proven or not brain metastases * Irradiated metastases * Inclusion in a treatment protocol for brain metastases by brain metastasis in toto or stereotactic or gamma-knife radiotherapy * Morphological increase of one or more lesions of secondary brain metastases on a follow-up MRI * Patients affiliated to a social security scheme Exclusion Criteria: * Opposition to the study * Contraindication to MRI * Refusal of imaging by the patient * Patient with state medical aid (unless exemption from affiliation) * Severe cognitive impairment making informed consent impossible * Patients under guardianship or deprived of liberty

Treatments Being Tested

RADIATION

MRI with CEST sequence, IVIM and ASL sequence

Three sequences will be added as part of the protocol (for an additional duration of about 10 minutes) : * The CEST sequence * The ASL infusion sequence * The IVIM sequence

Locations (1)

Hôpital Bichat-Claude Bernard
Paris, France