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RECRUITINGINTERVENTIONAL

Multimodal Study of the Human Brain Epilepsy Tissue

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The TIPI2 study is a blood and tissue collection protocol to create an annotated biorepository to support research in drug-resistant epilepsy. The aim of the study will be to identify new pathophysiological pathways. For this purpose, the investigators will investigate with a multimodal approach blood and brain samples from patients undergoing a surgery for focal drug-resistant epilepsy. The adult patients will be enrolled either during the pre-surgical evaluation or right before the surgery.

Who May Be Eligible (Plain English)

Who May Qualify: - 18 yo or above - patients with a focal drug-resistant epilepsy - patients hospitalized for a pre-surgical evaluation or for an epilepsy surgery - consent obtained from the patient, or legally authorized representative - affiliated to a social security system Who Should NOT Join This Trial: - None Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * 18 yo or above * patients with a focal drug-resistant epilepsy * patients hospitalized for a pre-surgical evaluation or for an epilepsy surgery * consent obtained from the patient, or legally authorized representative * affiliated to a social security system Exclusion Criteria: * None

Treatments Being Tested

OTHER

Blood and tissue collection

Blood will be collected for group 1 during (i) the enrolment visit, (ii) in the 24 hours following a seizure, (iii)before the surgery and (iv) in the 36 months following the surgery. The left-over tissue, not useful for diagnostic purpose, will be kept for research. Blood will be collected for group 2 right before the surgery and in the 36 months following the surgery. The left-over tissue not useful for diagnostic purpose will be kept for research.

Locations (1)

Department of Neurology, Epilepsy Unit, Pitié-Salpêtrière Hospital
Paris, France