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RECRUITINGINTERVENTIONAL

Effect of Timed-Restricted Eating on Metabolic Health

The Effect of Timed-Restricted Eating on Insulin Sensitivity, De Novo Lipogenesis and Liver Fat in Subjects With Obesity and Insulin Resistance

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin resistance.

Who May Be Eligible (Plain English)

Who May Qualify: - Ability to provide willing to sign a consent form; - BMI \> 30kg/m\^2; - Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L; - Stable weight for 3 months prior to study inclusion - For women, 1 year after last menstrual cycle Who Should NOT Join This Trial: - Use of any medication, except for those related to treatment of metabolic syndrome; - Any medical condition interfering with study outcomes or design; - History of any psychiatric disorder, including eating disorders; - Performing shift work - Performing intensive sports (\>3 hours/week); - Smoking; - Drugs abuse or alcohol abuse (\>3 units/day); - Contraindication for MRI; - Known lactose/gluten intolerance; - Known soy, egg, milk or peanut allergy; - Childhood onset of obesity Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Ability to provide informed consent; * BMI \> 30kg/m\^2; * Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L; * Stable weight for 3 months prior to study inclusion * For women, 1 year after last menstrual cycle Exclusion Criteria: * Use of any medication, except for those related to treatment of metabolic syndrome; * Any medical condition interfering with study outcomes or design; * History of any psychiatric disorder, including eating disorders; * Performing shift work * Performing intensive sports (\>3 hours/week); * Smoking; * Drugs abuse or alcohol abuse (\>3 units/day); * Contraindication for MRI; * Known lactose/gluten intolerance; * Known soy, egg, milk or peanut allergy; * Childhood onset of obesity

Treatments Being Tested

BEHAVIORAL

Early time restricted eating

Subjects will follow an isocaloric diet, designed by a dietician. The eating window for the early-TRE group is between 7 AM - 5 PM

BEHAVIORAL

Late time restricted eating

Subjects will follow an isocaloric diet, designed by a dietician. The eating window for the late-TRE group is between 10 AM - 8 PM

Locations (1)

Amsterdam UMC, location AMC
Amsterdam, North Holland, Netherlands