Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

Who May Qualify: - Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category) - Require inpatient stabilization for SI or actions based on clinical observation and interview - Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus - Have a Glasgow Coma Score (GCS) of 15 - Age 18-65 Who Should NOT Join This Trial: - Current or past history of psychosis - Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater - History of ketamine use disorder - History of liver transplant - Pregnancy or breastfeeding - Imprisonment or inability to consent - Positive urine drug screen or serum alcohol level - Hypertension (SBP \> 160 or DBP \> 100 before administration of ketamine) - Hypotension (SBP \< 90) - Presence of acute medical condition requiring admission to medical service - Allergy, intolerance, or previous adverse reaction to ketamine - Patient has 8+ lifetime ketamine exposures - The treating physician determines that the patient is not a good candidate for the study (e.g. medical condition/procedure, medication that would contradindicate ketamine treatment) Always talk to your doctor about whether this trial is right for you.