Skip to main content
TTrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor.
RECRUITINGINTERVENTIONAL

CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study

Pilot Study Evaluating Supervised Cardiac Rehabilitation in Patients With Cardiac Amyloidosis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Exercise training in patients with heart failure and preserved ejection fraction (HFpEF) has been associated with an improvement in cardiorespiratory fitness and quality of life.

Who May Be Eligible (Plain English)

Who May Qualify: - Age \> 18 - New York Heart Association (NYHA) Class I-III Heart Failure - Able to Exercise - On stable treatment for their cardiac amyloidosis or under active surveillance - expected to live at least 6 months - Ability to understand and the willingness to sign a written willing to sign a consent form document in English, and the willingness/ability to comply with the protocol activities - Participant must be able and willing to follow the cardiac rehabilitation activities Who Should NOT Join This Trial: - Inability to provide willing to sign a consent form - Inability to commit to in-person supervised exercise sessions for three one-hour sessions a week for 12 weeks - NYHA Class IV Heart Failure - Pulmonary disease requiring home oxygen - Gait instability or history of prior falls - In the opinion of the Principal Investigator, have a clinically significant comorbid disease that is likely to affect the ability of the patient to complete the trial, interfere with their ability with measurement of self-reported outcomes. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age \> 18 * New York Heart Association (NYHA) Class I-III Heart Failure * Able to Exercise * On stable treatment for their cardiac amyloidosis or under active surveillance * Life expectancy of at least 6 months * Ability to understand and the willingness to sign a written informed consent document in English, and the willingness/ability to comply with the protocol activities * Participant must be able and willing to follow the cardiac rehabilitation activities Exclusion Criteria: * Inability to provide informed consent * Inability to commit to in-person supervised exercise sessions for three one-hour sessions a week for 12 weeks * NYHA Class IV Heart Failure * Pulmonary disease requiring home oxygen * Gait instability or history of prior falls * In the opinion of the Principal Investigator, have a clinically significant comorbid disease that is likely to affect the ability of the patient to complete the trial, interfere with their ability with measurement of self-reported outcomes.

Treatments Being Tested

BEHAVIORAL

• Cardiac Rehabilitation

Intervention group will have baseline 6-minute walk test and cardiopulmonary exercise test (CPET) testing followed by supervised cardiac rehabilitation program including planned 3 one hour sessions a week for a total of 12 weeks (planned 36 sessions). A post intervention 6-minute walk test and CPET test will be performed within 2 weeks of completion of the 12 week program.

Locations (1)

Sanger Heart and Vascular Institute
Charlotte, North Carolina, United States