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RECRUITINGINTERVENTIONAL

Investigation of the Frequency of Hereditary Hyper Alpha-tryptasemia in Patients With Elevated Basal Tryptasemia

Investigation of the Frequency of Hereditary Hyper Alpha-tryptasemia in Patients With Elevated Basal Tryptasemia (Protocol HaT)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of the study is to assess the number of patients with elevated blood tryptase for whom this elevation could be linked to a hereditary alpha-tryptase secretion abnormality or hyper-alpha-tryptasemia. This information will enable to better optimize the management and follow-up of patients who have experienced hypersensitivity reactions and have elevated basal blood tryptase levels. The patients will be offered the opportunity to take part in the study. If they consent to participate, they will be tested for hereditary hyper-alpha-tryptasemia. A blood sampling will be performed in the center. A few weeks after, the patient will be informed about the blood sample result during a medical consultation organized in the center.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients who came in the pneumoallergology department of the CHU de Nice since January 2014 for an allergological workup - Patients who have received at least one basal tryptase assay, according to recommendations - willing to sign a consent form signature Who Should NOT Join This Trial: - High tryptasemia (≥ 8ng/ml) synchronous with anaphylactic reaction and unconfirmed basally - Known diagnosis of systemic mastocytosis Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients who came in the pneumoallergology department of the CHU de Nice since January 2014 for an allergological workup * Patients who have received at least one basal tryptase assay, according to recommendations * informed consent signature Exclusion Criteria: * High tryptasemia (≥ 8ng/ml) synchronous with anaphylactic reaction and unconfirmed basally * Known diagnosis of systemic mastocytosis

Treatments Being Tested

GENETIC

Serum

Patients who came to the pneumoallergology department of the CHU de Nice since January 2014 for an allergological workup and with tryptasemia was ≥ 8ng/ml (at least once in patient history).

Locations (1)

CHU de Nice - Hôpital de Pasteur
Nice, Alpes-Maritimes, France