Reverse-Engineering of Exclusive Enteral Nutrition (RE-EEN) in Crohn's Disease: A Multi-Center Trial

Who May Qualify: - Age 8 -21 years old. - Diagnosis of Crohn's disease within 24 months - Elevation in objective inflammatory markers at enrollment: C-reactive protein (CRP), ESR, or fecal calprotectin - Active Crohn's disease, as defined by Pediatric Crohn's Disease Activity Index (PCDAI) ≥10. - Participant capable of giving willing to sign a consent form, or if a minor the parent/guardian is capable of giving willing to sign a consent form. Who Should NOT Join This Trial: - History of surgery for Crohn's disease. - Perianal disease as part of Crohn's disease phenotype. - Recent use of: - corticosteroids (within 4 weeks), - dose adjustment of immunomodulator (within 8 week) - azathioprine 4 weeks prior to study final visit (week 8) - start or adjust methotrexate 3 weeks prior to final study visit. - Prior use of biological medication - Prior treatment with EEN or other dietary therapy for Crohn's disease. - Prior treatment with antibiotics for Crohn's disease. - Known allergies to any of the food components in the smoothie. - Admission to hospital due to severity of Crohn's disease and associated symptoms. - Unwillingness to provide willing to sign a consent form. Always talk to your doctor about whether this trial is right for you.