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RECRUITINGPhase 2 / Phase 3INTERVENTIONAL

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

Who May Be Eligible (Plain English)

Who May Qualify: - age 21-55 - fluent in English - diagnosis of mood, anxiety, or traumatic stress disorder - clinically elevated repetitive negative thinking - outpatient status - 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications Who Should NOT Join This Trial: - past year diagnosis of severe alcohol or moderate or greater substance use disorder - lifetime history of psychotic or bipolar I disorder - acute suicidality necessitating immediate clinical intervention - neurodegenerative or neurodevelopmental disorders - history of moderate or severe traumatic brain injury or other known neurological condition - sensory deficits that would preclude completing tasks - conditions unsafe for completing MRI scanning (e.g., metal in body) - current pregnancy - currently receiving psychosocial treatment - currently receiving psychiatric pharmacotherapy, except SSRIs Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * age 21-55 * fluent in English * diagnosis of mood, anxiety, or traumatic stress disorder * clinically elevated repetitive negative thinking * outpatient status * 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications Exclusion Criteria: * past year diagnosis of severe alcohol or moderate or greater substance use disorder * lifetime history of psychotic or bipolar I disorder * acute suicidality necessitating immediate clinical intervention * neurodegenerative or neurodevelopmental disorders * history of moderate or severe traumatic brain injury or other known neurological condition * sensory deficits that would preclude completing tasks * conditions unsafe for completing MRI scanning (e.g., metal in body) * current pregnancy * currently receiving psychosocial treatment * currently receiving psychiatric pharmacotherapy, except SSRIs

Treatments Being Tested

BEHAVIORAL

COGENT

COGENT is based on a working memory capacity task, which requires individuals to memorize stimuli while simultaneously completing a secondary puzzle task.

OTHER

Sham Program

The Sham Program will be a similar task which researchers think will be less effective in training thinking skills.

Locations (1)

UC San Diego
San Diego, California, United States