RECRUITINGOBSERVATIONAL
Detection of Aneuploidy in Cell Free DNA to Improve the Sensitivity of Diagnostic Peritoneal Lavage in Gastric Cancer
About This Trial
Aneuploidy may be used as a more sensitive diagnostic tool to detect peritoneal metastasis compared to conventional cytology and imaging techniques. Our aim is to establish whether aneuploidy as detected in cfDNA (as a measure for ctDNA) in PLF of patients with GC may hold value as an additional staging and tumor evaluation method in GC patients.
Who May Be Eligible (Plain English)
Gastric cancer patients:
Who May Qualify:
- Age ≥18 years old;
- Written willing to sign a consent form according to the ICH-GCP and national/local regula-tions.
Who Should NOT Join This Trial:
\- Language difficulty, dementia or altered mental status prohibiting the under-standing and giving of willing to sign a consent form.
non-cancer controls:
Who May Qualify:
- Operable patients who will undergo a planned diagnostic laparoscopy for a benign indication bariatric or gallbladder disease);
- Age ≥18 years old;
- Written willing to sign a consent form according to the ICH-GCP and national/local regulations.
Who Should NOT Join This Trial:
- Active inflammation or infection;
- Subjects with previous malignancies are excluded unless a complete remission was achieved at least 5 years prior to study entry (exceptions include but are not limited to, non-melanoma skin cancers; in situ bladder cancer, or in situ co-lon cancers; in situ cervical cancers/dysplasia; or breast carcinoma in situ).
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Gastric cancer patients:
Inclusion Criteria:
* Age ≥18 years old;
* Written informed consent according to the ICH-GCP and national/local regula-tions.
Exclusion Criteria:
\- Language difficulty, dementia or altered mental status prohibiting the under-standing and giving of informed consent.
non-cancer controls:
Inclusion criteria:
* Operable patients who will undergo a planned diagnostic laparoscopy for a benign indication bariatric or gallbladder disease);
* Age ≥18 years old;
* Written informed consent according to the ICH-GCP and national/local regulations.
Exclusion criteria:
* Active inflammation or infection;
* Subjects with previous malignancies are excluded unless a complete remission was achieved at least 5 years prior to study entry (exceptions include but are not limited to, non-melanoma skin cancers; in situ bladder cancer, or in situ co-lon cancers; in situ cervical cancers/dysplasia; or breast carcinoma in situ).
Treatments Being Tested
OTHER
collection additional peritoneal lavage fluid
collection additional peritoneal lavage fluid
Locations (1)
Erasmus MC
Rotterdam, Netherlands