RECRUITINGINTERVENTIONAL
Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial
Effect of CPAP Treatment on Asthma Control in Patients With Severe Uncontrolled Asthma and Obstructive Sleep Apnea: The ASTHMA-SLEEP Study
About This Trial
The aim of the study is to evaluate the impact of CPAP treatment on asthma control in patients with severe uncontrolled asthma and obstructive sleep apnea (OSA)
Who May Be Eligible (Plain English)
Who May Qualify:
- Age \>18 years
- Diagnosis of severe uncontrolled asthma according to the criteria of the Spanish Asthma Management Guide (GEMA) or the Global Initiative for Asthma (GINA) and no hospitalizations the month prior to inclusion in the study.
- Apnea hypopnea rate greater than or equal to 15/hour
- Punctuation in the Epworth Sleepiness Scale ≤10
- Obtaining willing to sign a consent form.
Who Should NOT Join This Trial:
- Previous treatment with CPAP
- Patient with central sleep apnea or Cheyne-Stokes respiration
- Other sleep disorders: narcolepsy, restless leg syndrome, chronic insomnia,
- Resistant hypertension
- Active Smoking
- Unstable comorbidities or medications may interfere with asthma control
- Pregnancy
- Any process that reduces life expectancy to \<1 year,
- Any medical or social factor that may limit CPAP compliance
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Age \>18 years
* Diagnosis of severe uncontrolled asthma according to the criteria of the Spanish Asthma Management Guide (GEMA) or the Global Initiative for Asthma (GINA) and no hospitalizations the month prior to inclusion in the study.
* Apnea hypopnea rate greater than or equal to 15/hour
* Punctuation in the Epworth Sleepiness Scale ≤10
* Obtaining informed consent.
Exclusion Criteria:
* Previous treatment with CPAP
* Patient with central sleep apnea or Cheyne-Stokes respiration
* Other sleep disorders: narcolepsy, restless leg syndrome, chronic insomnia,
* Resistant hypertension
* Active Smoking
* Unstable comorbidities or medications may interfere with asthma control
* Pregnancy
* Any process that reduces life expectancy to \<1 year,
* Any medical or social factor that may limit CPAP compliance
Treatments Being Tested
DEVICE
CPAP treatment
Subjects allocated to this arm will receive continuous positive airway pressure (CPAP)
OTHER
Hygienic and dietary advice
Subjects allocated to this arm will receive hygienic and dietary counselling
Locations (1)
Hospital Clinic Barcelona
Barcelona, Spain, Spain