Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE
Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE - a Randomized, Double-blind, Placebo-controlled, Trial (ELIMINATE Trial)
About This Trial
The goal of this randomized, double-blind, placebo-controlled clinical trial is to investigate the immunological effects of influenza vaccination outside of the influenza season on arterial inflammation in patients with a recent acute myocardial infarction (AMI). The primary objective is to compare the effects of influenza vaccination to those of a placebo in reducing post-myocardial infarction coronary inflammation as measured by coronary computed tomography angiography (CCTA). The main questions it aims to answer are: Does influenza vaccination reduce arterial inflammation as measured by CCTA at week 8 after percutaneous coronary intervention (PCI) in comparison to baseline? Does influenza vaccination modulate systemic inflammation as measured by blood biomarkers and in-vitro challenge tests at week 8 after PCI in comparison to baseline? Researchers will compare the effects of influenza vaccination with those of a placebo.
Who May Be Eligible (Plain English)
Original Eligibility Criteria
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Treatments Being Tested
Influenza vaccine
VaxigripTetra Suspension for injection, 0,5ml prefilled syringe ATC code: J07BB02
Placebo
Sodium Chloride Solution for infusion, 9mg/ml ATC code: B05BB01