RECRUITINGINTERVENTIONAL

APA and PAS Training for Gait Initiation in Parkinson's Disease

Gait-initiation Related APA Training in Individuals With Parkinson Disease -Explicit Training and Paired Associative Stimulation(PAS) Priming

About This Trial

Our research focused on understanding the interplay between brain excitability and balance function in patients with Parkinson's disease (PD), alongside evaluating effective physical therapy methods. It highlights the prevalence of non-motor disorders and cognitive impairments among PD patients, including balance and postural issues, cognitive function decline, and gait instability. Additionally, it notes that PD patients exhibit abnormal electrophysiological responses, indicating altered central excitability.

Who May Be Eligible (Plain English)

Health subjects: Who Should NOT Join This Trial: - Musculoskeletal injuries on legs. - Osteoporosis. PD subjects: Who May Qualify: \- Clinical diagnosis of Parkinson disease. Who Should NOT Join This Trial: - Musculoskeletal injuries on legs - Osteoporosis. - Any peripheral or central nervous system injury or disease patients. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Health subjects: Exclusion Criteria: * Musculoskeletal injuries on legs. * Osteoporosis. PD subjects: Inclusion Criteria: \- Clinical diagnosis of Parkinson disease. Exclusion Criteria: * Musculoskeletal injuries on legs * Osteoporosis. * Any peripheral or central nervous system injury or disease patients.

Treatments Being Tested

OTHER

Weight shift training and APA feedback

Use COP trajectory to train weight shift on force plate. To give APA visual feedback for subjects after weight shift training.

PROCEDURE

Paired associative stimulation

Use TMS combine ES to stimulate TA nerve and M1 cortical

Locations (1)

Chang Gung University

Taoyuan District, Taiwan