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RECRUITINGINTERVENTIONAL

Resistance Training and Corticospinal Excitability in Multiple Sclerosis

Effects of Supervised Progressive Resistance Training on Central Nervous System Functioning (Corticospinal Excitability) and Walking Capacity in Persons With Multiple Sclerosis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of the present study is to investigate effects of progressive resistance training on central nervous system functioning (corticospinal excitability (CSE)) and walking capacity in persons with multiple sclerosis (pwMS). A total of 54 pwMS will be enrolled and randomized into 1 of 3 groups: high dose resistant training (RT), low dose RT, and waitlist control.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥ 18 years - MS diagnosis according to the McDonald diagnostic criteria - Shows impairments in walking capacity - Ability to self transport to test and exercise Who Should NOT Join This Trial: - Pregnancy - Neurological or other comorbidities that affects the nervous system - Relapse within the past 2 months - Pacemaker or metallic implants - Hypertension (medically unregulated) - Participation in structured RT over the past 3 months (≥ 2 sessions/week). Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age ≥ 18 years * MS diagnosis according to the McDonald diagnostic criteria * Shows impairments in walking capacity * Ability to self transport to test and exercise Exclusion Criteria: * Pregnancy * Neurological or other comorbidities that affects the nervous system * Relapse within the past 2 months * Pacemaker or metallic implants * Hypertension (medically unregulated) * Participation in structured RT over the past 3 months (≥ 2 sessions/week).

Treatments Being Tested

BEHAVIORAL

Progressive resistance training

The RT exercise regime will focus on lower extremity exercises (60-90% of 1 repetition maximum) as well as incorporating functional exercises.

Locations (2)

Department of Public Health
Aarhus, Central Jutland, Denmark
Department of Nutrition, Exercise and Sports, University of Copenhagen
Copenhagen, Copenhagen N, Denmark