RECRUITINGINTERVENTIONAL
Topical Application of PRF Before Radiation Therapy
Topical Application of PRF in Tooth Extraction Sockets Before Radiation Therapy for Head and Neck Cancer
About This Trial
The primary goal of this study is to observe whether PRP promotes the wound healing before a radiation therapy or not, compared to the natural healing of a tooth extraction socket. Secondary aim is to monitore the effect on the pain perception.
Who May Be Eligible (Plain English)
Who May Qualify:
- Head and neck cancer with planed radiation therapy
- Bilateral tooth extraction
- Similar tooth size
- Atraumatic tooth extractions without flap surgery
- Patients age above 18y of age
Who Should NOT Join This Trial:
- Prior radiation therapy in the head and neck area
- Prior and current therapy with bisphosphonates or equivalent modern biologics
- Patients during pregnancy or breastfeeding
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Head and neck cancer with planed radiation therapy
* Bilateral tooth extraction
* Similar tooth size
* Atraumatic tooth extractions without flap surgery
* Patients age above 18y of age
Exclusion Criteria:
* Prior radiation therapy in the head and neck area
* Prior and current therapy with bisphosphonates or equivalent modern biologics
* Patients during pregnancy or breastfeeding
Treatments Being Tested
PROCEDURE
PRF
Patients blood is standardized centrifuged and split in to a red-phase (erythrocytes) and white-phase (PRF). The gained PRF is processed to a clot-fort and is inserted into the alveolus.
PROCEDURE
Natural Healing
After the tooth extraction, natural healing is aimed by allowing a blood clot formation without any further intervention.
Locations (1)
University of Giessen
Giessen, Hesse, Germany