RECRUITINGINTERVENTIONAL
VIsualization of Coronary Artery Disease for Modification of RISK Factors
VIsualization of Coronary Artery Disease for Modification of RISK Factors. Prevention of Disease Progression in Patients With Non-Obstructive Coronary Atherosclerosis.
About This Trial
The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol lowering medications, and modify the coronary artery disease phenotype over 12 months.
Who May Be Eligible (Plain English)
Who May Qualify:
- New diagnosis of nonobstructive coronary artery disease
- No known coronary artery disease (no previous coronary revascularization)
- CAD-Rads score 1-3
- LDL cholesterol \> 2.0 mmol/l
- Life expectancy \>3 years
- Signed willing to sign a consent form
Who Should NOT Join This Trial:
- Post CTA test indication for invasive coronary angiography
- Non-evaluable CTA exam
- Obstructive coronary disease (One or more coronary stenosis ≥70%, left main \>40%)
- Ongoing lipid lowering medical treatment (Patients already on lipid lowering medical therapy can be included if the treatment was initiated \<3 months before the time of the CTA test)
- BMI \>40
- Renal insufficiency (eGFR \<40 ml/min)
- Allergy to iodinated contrast media
- Contraindications to statins (Active liver disease Child-Pugh A, B and C, excessive alcohol consumption)
- Participation in a cardiac rehabilitation or lifestyle modification program
- Pregnancy
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* New diagnosis of nonobstructive coronary artery disease
* No known coronary artery disease (no previous coronary revascularization)
* CAD-Rads score 1-3
* LDL cholesterol \> 2.0 mmol/l
* Life expectancy \>3 years
* Signed informed consent
Exclusion Criteria:
* Post CTA test indication for invasive coronary angiography
* Non-evaluable CTA exam
* Obstructive coronary disease (One or more coronary stenosis ≥70%, left main \>40%)
* Ongoing lipid lowering medical treatment (Patients already on lipid lowering medical therapy can be included if the treatment was initiated \<3 months before the time of the CTA test)
* BMI \>40
* Renal insufficiency (eGFR \<40 ml/min)
* Allergy to iodinated contrast media
* Contraindications to statins (Active liver disease Child-Pugh A, B and C, excessive alcohol consumption)
* Participation in a cardiac rehabilitation or lifestyle modification program
* Pregnancy
Treatments Being Tested
OTHER
Follow up at general practice
As described before
OTHER
Consultation
As described before
OTHER
Visualization of CTA images
As described before
Locations (5)
Gødstrup Hospital
Gødstrup, Jutland, Denmark
Aalborg University Hospital
Aalborg, Denmark
Bjarne L Nørgaard
Aarhus, Denmark
Hospital of South West Jutland
Esbjerg, Denmark
Vejle Hospital
Vejle, Denmark