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RECRUITINGOBSERVATIONAL

Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.

The Adipose Tissue and Sex-specific Role of Adipose-derived Extracellular Vesicles in Obesity-related Skeletal Muscle Insulin Resistance.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.

Who May Be Eligible (Plain English)

Individuals with obesity - Who May Qualify: - Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m\^2 and are scheduled for their first bariatric surgery. - Final male/female ratio of this study is 1:1 - Minimal knowledge of Dutch to read and understand the willing to sign a consent form. Individuals with obesity - Who Should NOT Join This Trial: - Smoking and/or drug abuse - Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator) - Lung and/or kidney diseases - Brain and/or nerve diseases - Malignant diseases (e.g. cancer) Individuals without obesity (lean) - inclusion criteria - Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg/m\^2 and are scheduled for abdominal surgery - Female only - Minimal knowledge of Dutch to read and understand the willing to sign a consent form. Individuals without obesity (lean) - exclusion criteria - Smoking and/or drug abuse - Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator) - Lung and/or kidney diseases - Brain and/or nerve diseases - Endocrine diseases like type 2 diabetes - Malignant diseases (e.g. cancer) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Individuals with obesity - Inclusion Criteria: * Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m\^2 and are scheduled for their first bariatric surgery. * Final male/female ratio of this study is 1:1 * Minimal knowledge of Dutch to read and understand the informed consent. Individuals with obesity - Exclusion Criteria: * Smoking and/or drug abuse * Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator) * Lung and/or kidney diseases * Brain and/or nerve diseases * Malignant diseases (e.g. cancer) Individuals without obesity (lean) - inclusion criteria * Caucasian adults with obesity that have a body mass index (BMI) of between 18 and 24.9 kg/m\^2 and are scheduled for abdominal surgery * Female only * Minimal knowledge of Dutch to read and understand the informed consent. Individuals without obesity (lean) - exclusion criteria * Smoking and/or drug abuse * Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator) * Lung and/or kidney diseases * Brain and/or nerve diseases * Endocrine diseases like type 2 diabetes * Malignant diseases (e.g. cancer)

Treatments Being Tested

OTHER

Adipose tissue biopsy

From each patient, two biopsies will be taken during surgery; one from the subcutaneous and one from the visceral adipose tissue.

OTHER

Blood sampling

From each patient, two venous blood samples (citrate, LiHe and EDTA plasma) will be taken before surgery.

OTHER

Questionnaire

Before bariatric surgery, every patient will fill out questions about general health (physical activity, sedentary behavior, sleeping pattern, ...), physical condition before surgery (nausea, food intake, ...), etc.

OTHER

Patient phenotyping

Length and weight will be measured to calculate body mass index (BMI). Waist and hip circumference will be assessed, as well as blood pressure (both systolic and diastolic) and heart rate at rest. Body composition will be determined using a bioelectrical impedance analysis (BIA) in the hospital. Medication use and comorbidities (that are allowed within the in-/exclusion criteria) will also be derived from the patient's medical files with patient's permission.

Locations (1)

Ziekenhuis Oost-Limburg
Genk, Limburg, Belgium