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RECRUITINGINTERVENTIONAL

Brief Motivational Intervention (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users

Impact of Identification and Brief Motivational Intervention in Dispensing Pharmacies (BMI) on the Deprescription of Benzodiazepines and Related Substances in Adult Chronic Drug Users

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

We hypothesise that a short-term intervention by dispensing pharmacists is feasible and relatively easy to implement, and that it could have an impact on the deprescribing of BZD/Z in adult patients. Two primary objectives will be evaluated in a sequential hierarchical manner, with two primary endpoints analysed one after the other, without alpha risk adjustment, but the second can only be analysed if the null hypothesis is rejected for the first: 1. Evaluate the impact of brief motivational intervention (BMI) on reducing the daily dose of BZD/Z prescribed at 6 months (superiority hypothesis) compared with the usual practice of dispensing BZD/Z in pharmacies. 2. Evaluate the impact of BMI on clinical worsening at 6 months (non-inferiority hypothesis) in comparison with the usual practice of dispensing BZD/Z in pharmacies.

Who May Be Eligible (Plain English)

Who May Qualify: - Continuous treatment (at least once daily) with BZD/Z for at least 6 months, after verification of 6 months' supply. - Signed willing to sign a consent form - Patient able to understand the survey and complete a questionnaire in French. - Affiliation with the French social security system Who Should NOT Join This Trial: - Concomitant treatment with: - The following oral antipsychotics: risperidone, olanzapine, aripiprazole, quetiapine, clozapine, haloperidol, flupentixol, pimozide, chlorpromazine, sulpiride, zuclopenthixol, loxapine, cyamemazine (\>100mg/D), sulpiride (\>150mg/D), - Injectable medium- and long-acting antipsychotics - Thymoregulatory treatment with lithium - Treatments for alcohol use disorders: baclofen, nalmefene, naltrexone, acamprosate, disulfiram - Opiate substitution treatments: buprenorphine, methadone - Anti-epileptic drugs - History of convulsions or epilepsy - History of gabaergic withdrawal accidents: delirium tremens, confusional syndrome requiring specialist treatment (hospitalisation, specialist consultation), epileptic seizures, etc. - Patients suffering from cancer - Persons referred to in articles L1121-5 to L1121-8 of the French Public Health Code (corresponding to all protected persons: pregnant women, women in childbirth, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons subject to a legal protection measure). Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Continuous treatment (at least once daily) with BZD/Z for at least 6 months, after verification of 6 months' supply. * Signed informed consent * Patient able to understand the survey and complete a questionnaire in French. * Affiliation with the French social security system Exclusion Criteria: * Concomitant treatment with: * The following oral antipsychotics: risperidone, olanzapine, aripiprazole, quetiapine, clozapine, haloperidol, flupentixol, pimozide, chlorpromazine, sulpiride, zuclopenthixol, loxapine, cyamemazine (\>100mg/D), sulpiride (\>150mg/D), * Injectable medium- and long-acting antipsychotics * Thymoregulatory treatment with lithium * Treatments for alcohol use disorders: baclofen, nalmefene, naltrexone, acamprosate, disulfiram * Opiate substitution treatments: buprenorphine, methadone * Anti-epileptic drugs * History of convulsions or epilepsy * History of gabaergic withdrawal accidents: delirium tremens, confusional syndrome requiring specialist treatment (hospitalisation, specialist consultation), epileptic seizures, etc. * Patients suffering from cancer * Persons referred to in articles L1121-5 to L1121-8 of the French Public Health Code (corresponding to all protected persons: pregnant women, women in childbirth, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons subject to a legal protection measure).

Treatments Being Tested

OTHER

Brief motivational intervention

identification followed by a brief motivational intervention in pharmacies (BMI) based on the mobilisation of patients' psychosocial skills and the integration of tools to help reduce consumption of BZD/Z prescribed over the long term (≥ 6 months).

Locations (20)

Pharmacie Riffard Annonay
Annonay, France
Pharmacie du Village
Auriol, France
Pharmacie des Champs Dolent
Beauvais, France
Pharmacie Troisgros
Cap-d'Ail, France
Pharmacie des Fontanilles
Castelnaudary, France
Pharmacie Dolus d'Oléron
Dolus-d'Oléron, France
Pharmacie de Dommartin
Dommartin, France
Pharmacie du Mont Guillaume
Embrun, France
Ma Pharmacie Evenos
Évenos, France
Pharmacie du Pog
Lavelanet, France
Pharmacie de Lentilly
Lentilly, France
Pharmacie Thomas
Ludres, France
Pharmacie Saint Pierre Marignane
Marignane, France
Pharmacie Milan Saint-Giniez
Marseille, France
Pharmacie de la Sèvre
Moncoutant, France
Pharmacie de St georges
Saint-Georges-de-Reineins, France
Pharmacie du Théâtre
Saint-Omer, France
Pharmacie du Château
Saint-Porchaire, France
Pharmacie Labarrière
Savigné-l'Évêque, France
Pharmacie de l'Ermitage
Villemoisson-sur-Orge, France