Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock

Who May Qualify: - patients suffering from septic shock hospitalized in an intensive setting - patients over 18 years and under 80 years of age - patients within 24 hours of clinical diagnosis, and requiring, in this time window, a norepinephrine dosage equal to or greater than 0.25 mcg/kg/min according to the patient's ideal weight (IBW) - patients capable of expressing willing to sign a consent form to treatment. Who Should NOT Join This Trial: - patients in the absence of consent to participate in the study and to the processing of personal and particular data; - patients under 18 years of age or over 80 years of age; - patients who died within the first 24 hours of admission to the ICU; - patients requiring a norepinephrine dosage lower than 0.25 mcg/kg/min in the first 24 hours of hospitalization in the ICU; - patients with recent acute coronary syndrome (within the previous 7 days); - patients with allergy/intolerance to the drugs used in the study or to any component of the study drug including excipients; - pregnant patients; - breastfeeding individuals; - patients who need to start renal replacement treatment within 24 hours of admission to the ICU for dialysis emergencies that cannot be deferred; - patients with a history of end-stage renal failure or already undergoing dialysis treatment (CKD stages 4 and 5, with glomerular filtration \< 30 ml/min); - single kidney patients; - patients with bilateral renal hypoplasia; - patients undergoing kidney transplant; - patients undergoing haemoperfusion with an adsorbent cartridge for bacterial endotoxin. Always talk to your doctor about whether this trial is right for you.