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RECRUITINGINTERVENTIONAL

Validation of Hematological Indices

Validation of Hematological Indices as Prognostic Markers of Inflammatory Complications and Multiple Organ Dysfunction in Cardiac Surgery Patients.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The hypothesis of the study is that hematological indices (neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic index of inflammation) may be predictors of infectious complications and multiple organ dysfunction in patients after cardiac surgery.

Who May Be Eligible (Plain English)

Who May Qualify: - age from 18 to 80 years - cardiac surgery - operation in the conditions of cardiopulmonary bypass - availability of voluntary willing to sign a consent form of the patient to participate in the study Who Should NOT Join This Trial: - refusal of the patient from the study - transfer of the patient to another medical institution Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * age from 18 to 80 years * cardiac surgery * operation in the conditions of cardiopulmonary bypass * availability of voluntary informed consent of the patient to participate in the study Exclusion Criteria: * refusal of the patient from the study * transfer of the patient to another medical institution

Treatments Being Tested

DIAGNOSTIC_TEST

Determination of the level of the studied biomarkers

Determination of the level of hematological indices based on a general blood test; Determination of the levels of the following biomarkers: isolation of neutrophils from the blood using the gradient centrifugation method; assessment using enzyme immunoassay (ELISA) of the content of neutrophil elastase in the supernatant; myeloperoxidase, ELISA; lactoferrin, ELISA; interleukin -1ß,17,10,6, ELISA; presepsin, ELISA; endothelin, ELISA; lipopolysaccharide, LAL test; lipopolysaccharide binding protein, ELISA; NETs release, immunofluorescence method; the number of neutrophils expressing PDL-1, flow cytofluorimetry method; procalcitonin in human plasma and serum, VIDAS B.R.A.H.M.S. PCT; ferritin, reagent for determination (FERRITIN); lactate dehydrogenase, reagent for determination of QSR6128;Endotoxin Activity Assay, chemiluminescent immunodiagnostics.

Locations (1)

Petrovsky National Reasearch Centre of Surgery
Moscow, Russia