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RECRUITINGINTERVENTIONAL

Suicide Specific Rumination in Veterans

Reducing Suicide-Specific Rumination in Veterans Using Real-time Functional Magnetic Resonance Imaging Neurofeedback

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Few treatments target core features of suicidal thoughts and behaviors in Veterans. Real-time functional magnetic resonance imaging neurofeedback can provide information regarding brain activation associated with suicide-specific rumination, defined as a "repetitive mental fixation on one's suicidal thoughts and intentions." The goal of this feasibility study is for Veterans to learn strategies for modulating activity within brain regions that have been demonstrated to contribute to the maintenance of rumination, as they receive neurofeedback feedback signals from the brain.

Who May Be Eligible (Plain English)

Who May Qualify: - U.S. military veteran between 18-65 years old - negative pregnancy test on MRI scan days - score greater than or equal to 10 on the Suicide Rumination Scale - clinically stabilized on psychotropic medications - engaged in mental health care treatment - able to provide written, willing to sign a consent form Who Should NOT Join This Trial: - no major medical or neurological disorders that could interfere with treatment - moderate or severe traumatic brain injury - current imminent suicide risk, as determined through psychiatric interview, responses to C-SSRS, and clinical judgment of the assessor - any current psychotic disorder - MRI contraindications - any substance use disorder for substances other than cannabis or alcohol (mild alcohol or cannabis use disorder does not exclude participants but moderate or severe alcohol or cannabis substance use disorder is disqualifying) - pregnant or trying to become pregnant Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * U.S. military veteran between 18-65 years old * negative pregnancy test on MRI scan days * score greater than or equal to 10 on the Suicide Rumination Scale * clinically stabilized on psychotropic medications * engaged in mental health care treatment * able to provide written, informed consent Exclusion Criteria: * no major medical or neurological disorders that could interfere with treatment * moderate or severe traumatic brain injury * current imminent suicide risk, as determined through psychiatric interview, responses to C-SSRS, and clinical judgment of the assessor * any current psychotic disorder * MRI contraindications * any substance use disorder for substances other than cannabis or alcohol (mild alcohol or cannabis use disorder does not exclude participants but moderate or severe alcohol or cannabis substance use disorder is disqualifying) * pregnant or trying to become pregnant

Treatments Being Tested

BEHAVIORAL

Real Time fMRI Neurofeedback

The proposed pilot study is designed to collect feasibility and acceptability data regarding the utility of real-time functional magnetic resonance imaging (rt-fMRI) feedback in reducing suicide-specific rumination in veterans. Fifteen veterans will receive 2 rt-fMRI neurofeedback sessions while attempting to alter connectivity in brain regions that play a role in rumination. Pre- and post-treatment assessments of suicide, disability, functional impairment, and quality of life will be collected.

Locations (1)

James J. Peters VA Medical Center, Bronx, NY
The Bronx, New York, United States