RECRUITINGINTERVENTIONAL
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Dysfunction of Olfaction After SARS-CoV-2 Infection: Morphological and Histomolecular Investigation of Olfactory Cleft Biopsies and Cytobrushes
About This Trial
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.
Who May Be Eligible (Plain English)
Who May Qualify:
- Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10
- Control group: No OD (TDI-score \>30.5.)
Who Should NOT Join This Trial:
- Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations
- Use of anticoagulation therapy
- Allergy to local anesthetics
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10
* Control group: No OD (TDI-score \>30.5.)
Exclusion Criteria:
* Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations
* Use of anticoagulation therapy
* Allergy to local anesthetics
Treatments Being Tested
PROCEDURE
Biopsy and Cytobrush
Collection of olfactory cleft biopsies and cytobrushes
Locations (7)
Cliniques Universitaires Saint-Luc
Brussels, Brussels Capital, Belgium
UZ/KU Leuven
Leuven, Vlaams-Brabant, Belgium
AZ Sint-Jan Brugge
Bruges, West-Vlaanderen, Belgium
University Hospital Carl Gustav Carus
Dresden, Dresden, Germany
Max Planck Research Unit for Neurogenetics
Frankfurt am Main, Frankfurt, Germany
Hôpitaux Universitaires de Genève
Geneva, Canton of Geneva, Switzerland
University of Zurich and University Hospital Zurich
Zurich, Canton of Zurich, Switzerland