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RECRUITINGINTERVENTIONAL

Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation

Dysfunction of Olfaction After SARS-CoV-2 Infection: Morphological and Histomolecular Investigation of Olfactory Cleft Biopsies and Cytobrushes

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.

Who May Be Eligible (Plain English)

Who May Qualify: - Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10 - Control group: No OD (TDI-score \>30.5.) Who Should NOT Join This Trial: - Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations - Use of anticoagulation therapy - Allergy to local anesthetics Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10 * Control group: No OD (TDI-score \>30.5.) Exclusion Criteria: * Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations * Use of anticoagulation therapy * Allergy to local anesthetics

Treatments Being Tested

PROCEDURE

Biopsy and Cytobrush

Collection of olfactory cleft biopsies and cytobrushes

Locations (7)

Cliniques Universitaires Saint-Luc
Brussels, Brussels Capital, Belgium
UZ/KU Leuven
Leuven, Vlaams-Brabant, Belgium
AZ Sint-Jan Brugge
Bruges, West-Vlaanderen, Belgium
University Hospital Carl Gustav Carus
Dresden, Dresden, Germany
Max Planck Research Unit for Neurogenetics
Frankfurt am Main, Frankfurt, Germany
Hôpitaux Universitaires de Genève
Geneva, Canton of Geneva, Switzerland
University of Zurich and University Hospital Zurich
Zurich, Canton of Zurich, Switzerland