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RECRUITINGOBSERVATIONAL

Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis

Comparative Analysis of Clinical Outcomes and Inflammatory Responses in Viral Versus Bacterial Sepsis: A Retrospective Cohort Study in ICU Patients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This observational cohort study aims to compare clinical outcomes and inflammatory responses between patients with viral sepsis, specifically COVID-19-associated sepsis, and those with bacterial sepsis. Conducted at Sichuan Provincial People's Hospital, the study will retrospectively analyze data from ICU patients admitted between July 2021 and December 2023. The primary objective is to identify reliable biomarkers and diagnostic methods to improve patient outcomes through personalized diagnostic and therapeutic strategies.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Patients diagnosed with sepsis according to Sepsis 3.0 criteria. 2. Patients with confirmed bacterial sepsis based on positive bacterial cultures. 3. Patients with confirmed viral sepsis, specifically COVID-19, diagnosed via RT-PCR for SARS-CoV-2 for viral group and negative for bacterial group. 4. Patients aged 18 years and older. 5. Patients admitted to the ICU during the study period. Who Should NOT Join This Trial: 1. Patients with mixed bacterial and viral infections. 2. Patients with sepsis not meeting the Sepsis 3.0 criteria. 3. Patients who received immunomodulatory therapies other than standard treatments (e.g., investigational drugs). 4. Pregnant or breastfeeding women. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Patients diagnosed with sepsis according to Sepsis 3.0 criteria. 2. Patients with confirmed bacterial sepsis based on positive bacterial cultures. 3. Patients with confirmed viral sepsis, specifically COVID-19, diagnosed via RT-PCR for SARS-CoV-2 for viral group and negative for bacterial group. 4. Patients aged 18 years and older. 5. Patients admitted to the ICU during the study period. Exclusion Criteria: 1. Patients with mixed bacterial and viral infections. 2. Patients with sepsis not meeting the Sepsis 3.0 criteria. 3. Patients who received immunomodulatory therapies other than standard treatments (e.g., investigational drugs). 4. Pregnant or breastfeeding women.

Treatments Being Tested

OTHER

observation

data collected includes demographic information, clinical outcomes (mortality rate, ICU stay length), inflammatory markers (e.g., IL-2, IL-10, TNF-α), and treatment details (mechanical ventilation, CRRT, ECMO, antibiotics). Culture results, NGS findings, and imaging reports were also documented.

Locations (1)

Sichuan Provincial People's Hospital
Chengdu, Sichuan, China