Differential Thrombogenesis by EPA and DHA Mediated by HDL

Who May Qualify: - Fasting TG levels ≥ 150 mg/dL and \< 500 mg/dL and HDL-C ≤ 40 (men) or ≤ 50 (women) - LDL-C \> 40 mg/dL and ≤ 130 mg/dL - Able to provide willing to sign a consent form and adhere to study schedules - Agree to follow and maintain a relatively stable and low fatty fish intake diet (\<3 servings per week) Who Should NOT Join This Trial: - Female with pregnancy, planned pregnancy (within the study period), or currently breastfeeding. - Subjects with weight changes greater than 20% over the past 3 months - Subjects planning a significant change in diet or exercise levels - Malabsorption syndrome and/or chronic diarrhea - Use of dietary supplements containing n-3 PUFA fatty acids - Frequent consumption of n-3 PUFA-enriched fish (\>3 times a week) - Abnormal liver, kidney, or thyroid functions - Drug or alcohol abuse within 6 months or significant mental/psychological impairment - Current smokers - Subjects taking daily aspirin, NSAIDs, anticoagulant, or corticosteroids - Subjects with known bleeding disorders (for example, hemophilia) - Known sensitivity or allergy to fish, shellfish, or omega-3 fatty acid supplements - Subjects requiring regular transfusions for any reason - No ethnic/racial groups will be excluded Always talk to your doctor about whether this trial is right for you.