Updated June 2026 · ClinicalTrials.gov

RECRUITINGPhase 1 / Phase 2INTERVENTIONAL

Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection

Q: What is the NCT06510582 clinical trial studying?

The goal of this clinical trial is to test whether infusing bevacizumab into the middle meningeal arteries can be used to treat chronic subdural hematomas (cSDH). The main questions it aims to answer are: * Is bevacizumab infusion safe in cSDH patients? * Is bevacizumab infusion effective in treating cSDH? The full protocol is registered on ClinicalTrials.gov and includes the primary outcome measures, eligibility criteria, and study endpoints.

Q: Who can participate in NCT06510582?

Eligibility for this trial depends on the specific inclusion and exclusion criteria set by the sponsor. The plain-English summary above translates the most important criteria into accessible language; the official clinical text is preserved in the collapsible section underneath. Whether you fit any specific trial is a medical decision your doctor needs to confirm — bring the trial information to your treating physician for a full review against your medical history.

Q: How do I contact the trial site for NCT06510582?

Contact information registered with ClinicalTrials.gov is shown in the sidebar of this page. Before reaching out, confirm with your treating physician that this trial is appropriate for your situation. The trial site will then walk you through the screening process to determine final eligibility.

Q: Is participating in a clinical trial safe?

Clinical trials in the United States are regulated by the FDA and overseen by Institutional Review Boards (IRBs) that review the protocol for safety. Risk varies by trial — Phase 1 studies test new treatments in humans for the first time, while Phase 3 trials use treatments that have already passed earlier safety screening. The informed consent document for any specific trial details the known risks and what to expect. Discuss those risks with your physician before deciding whether to participate.

Q: Where can I verify the data on this page?

Every detail on this page comes directly from the ClinicalTrials.gov API. Click "View on ClinicalTrials.gov" in the sidebar to see the official, unmodified record. The federal record is always authoritative; this page is a structured presentation with a plain-English eligibility translation. For background on how clinical trials are regulated, see the FDA drug approval process documentation.

Chronic Subdural Hematoma Treatment With Avastin® (Bevacizumab) Intra-Arterial Injection: A Non-Randomized, Open-Label Phase 1/2 Clinical Trial

Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection (NCT06510582) is a Phase 1 / Phase 2 interventional studying Chronic Subdural Hematoma, sponsored by The Cooper Health System. RECRUITING as of the most recent ClinicalTrials.gov update. Talk to your doctor before contacting the trial site.

About This Trial

What Stage of Research Is This?

Phase 1 trials test a new treatment for the first time in humans, focusing on safety, dosing, and how the body processes the drug. For Chronic Subdural Hematoma, a Phase 1 study typically enrolls a small number of participants — often healthy volunteers or patients who have exhausted standard treatment options. Phase 1 results determine whether a treatment moves into larger Phase 2 efficacy studies.

This trial is currently recruiting participants. The sponsor has registered the study with ClinicalTrials.gov as actively enrolling, which means new applicants who meet the eligibility criteria can be considered for screening. Trial status can change between updates — confirm current recruiting status with the study contact before traveling for a screening visit.

Target enrollment of 140 participants puts this in the typical range for a Phase 2-style efficacy study or a moderate Phase 3 trial in a focused Chronic Subdural Hematoma subpopulation. At this scale, the study has enough statistical power to detect a clear treatment effect but is not the largest cohort in the field.

Who May Be Eligible (Plain English)

Who May Qualify: - Adult patients (≥18 years) - Radiographic evidence of chronic subdural hematoma, including 1. Persistence of subdural blood more than 10 days after index traumatic injury or event 2. Presence of mixed density blood 3. Presence of subdural membranes - Can obtain willing to sign a consent form and Health Insurance Portability and Accountability Act (HIPAA) authorization. Who Should NOT Join This Trial: - Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study. - Patients with concomitant intracranial pathology other than subdural hematoma (e.g., intracranial malignancy). - Patients with known hypersensitivity to bevacizumab. - Patients with radiographic evidence of mass effect. - Patients have focal neurological deficits attributed to subdural hematoma. - Patient had craniotomy or burr hole operative procedures performed in preceding two weeks prior to onset of subdural hematoma. - Secondary causes apart from trauma for the chronic subdural hematoma, such as underlying vascular abnormality or tumor. - Emergent surgical evacuation is required for the patient. - Non-convexity chronic subdural hematoma, as the middle meningeal artery will not supply this area. - Coagulation abnormalities, including platelet count \<100,000 and/or international normalized ratio of \<1.5 despite attempts for correction. - Patients with known contraindications for angiography. Patients with contrast allergy will be premedicated with diphenhydramine and steroids. - Patient has known active systemic infection or sepsis. - Patient has contradiction to anesthetic agents used for conscious sedation/monitored anesthesia care (MAC). - Patient has life expectancy of less than six months due to comorbid terminal conditions. - Patient has a premorbid modified Rankin score (mRS) of 5 or greater. - Concurrent participation in another research protocol for investigation of an experimental therapy. Always talk to your doctor about whether this trial is right for you.

These are translations of the protocol\'s inclusion and exclusion criteria, simplified for patients and caregivers. The original clinical text appears below. Eligibility is ultimately confirmed by the trial site\'s screening process — this summary is a starting point for a conversation with your doctor, not a final determination.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Adult patients (≥18 years) * Radiographic evidence of chronic subdural hematoma, including 1. Persistence of subdural blood more than 10 days after index traumatic injury or event 2. Presence of mixed density blood 3. Presence of subdural membranes * Can obtain informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization. Exclusion Criteria: * Pregnant, breastfeeding, or unwilling to practice contraception during participation in the study. * Patients with concomitant intracranial pathology other than subdural hematoma (e.g., intracranial malignancy). * Patients with known hypersensitivity to bevacizumab. * Patients with radiographic evidence of mass effect. * Patients have focal neurological deficits attributed to subdural hematoma. * Patient had craniotomy or burr hole operative procedures performed in preceding two weeks prior to onset of subdural hematoma. * Secondary causes apart from trauma for the chronic subdural hematoma, such as underlying vascular abnormality or tumor. * Emergent surgical evacuation is required for the patient. * Non-convexity chronic subdural hematoma, as the middle meningeal artery will not supply this area. * Coagulation abnormalities, including platelet count \<100,000 and/or international normalized ratio of \<1.5 despite attempts for correction. * Patients with known contraindications for angiography. Patients with contrast allergy will be premedicated with diphenhydramine and steroids. * Patient has known active systemic infection or sepsis. * Patient has contradiction to anesthetic agents used for conscious sedation/monitored anesthesia care (MAC). * Patient has life expectancy of less than six months due to comorbid terminal conditions. * Patient has a premorbid modified Rankin score (mRS) of 5 or greater. * Concurrent participation in another research protocol for investigation of an experimental therapy.

Treatments Being Tested

DRUG

Bevacizumab 2 mg/kg

Single 2mg/kg dose of bevacizumab to treat unilateral cSDH

DRUG

Bevacizumab 4 mg/kg

Two 2mg/kg doses (cumulatively 4mg/kg) of bevacizumab to treat bilateral cSDH

Locations (1)

Trial sites listed on ClinicalTrials.gov for this study. Site activation status can vary — confirm with the specific site before traveling for a screening visit.

Cooper University Health Care

Camden, New Jersey, United States

How to Talk to Your Doctor About This Trial

Bring the printable summary of this trial — including the NCT ID (NCT06510582), the sponsor (The Cooper Health System), and the key eligibility criteria — to your next appointment. Your doctor can review the inclusion and exclusion criteria against your medical history, lab values, and current treatments to assess whether you are likely to qualify. They can also help you weigh whether trial participation makes sense alongside your existing care plan.

Useful questions to walk through together: What does the trial protocol require beyond standard care? How long is the active treatment phase, and how long is follow-up? Are there study visits at sites I can reach? Who pays for the trial-specific procedures, and who pays for standard-of-care portions? See our 25 questions to ask about clinical trials guide for a more complete checklist.

Authoritative Sources

The official record for this trial lives on ClinicalTrials.gov — the federal registry maintained by the National Library of Medicine at NIH. For background on how this trial fits into the FDA approval pathway, see the FDA drug approval process. For oncology-specific guidance for patients considering trials, the National Cancer Institute publishes patient-oriented overviews. International trial registries are aggregated by the WHO ICTRP.

Frequently Asked Questions

What is the NCT06510582 clinical trial studying?

The goal of this clinical trial is to test whether infusing bevacizumab into the middle meningeal arteries can be used to treat chronic subdural hematomas (cSDH). The main questions it aims to answer are: * Is bevacizumab infusion safe in cSDH patients? * Is bevacizumab infusion effective in treating cSDH? The full protocol is registered on ClinicalTrials.gov and includes the primary outcome measures, eligibility criteria, and study endpoints.

Who can participate in NCT06510582?

Eligibility for this trial depends on the specific inclusion and exclusion criteria set by the sponsor. The plain-English summary above translates the most important criteria into accessible language; the official clinical text is preserved in the collapsible section underneath. Whether you fit any specific trial is a medical decision your doctor needs to confirm — bring the trial information to your treating physician for a full review against your medical history.

How do I contact the trial site for NCT06510582?

Contact information registered with ClinicalTrials.gov is shown in the sidebar of this page. Before reaching out, confirm with your treating physician that this trial is appropriate for your situation. The trial site will then walk you through the screening process to determine final eligibility.

Is participating in a clinical trial safe?

Clinical trials in the United States are regulated by the FDA and overseen by Institutional Review Boards (IRBs) that review the protocol for safety. Risk varies by trial — Phase 1 studies test new treatments in humans for the first time, while Phase 3 trials use treatments that have already passed earlier safety screening. The informed consent document for any specific trial details the known risks and what to expect. Discuss those risks with your physician before deciding whether to participate.

Where can I verify the data on this page?

Every detail on this page comes directly from the ClinicalTrials.gov API. Click "View on ClinicalTrials.gov" in the sidebar to see the official, unmodified record. The federal record is always authoritative; this page is a structured presentation with a plain-English eligibility translation. For background on how clinical trials are regulated, see the FDA drug approval process documentation.

How This Page Is Built

Every field on this page is pulled directly from the ClinicalTrials.gov API v2 — no estimates, no proxies. The plain-English eligibility translation is generated from the original protocol text and reviewed for fidelity to the underlying clinical criteria. The original clinical text remains visible in the collapsible section above so users and clinicians can verify the translation. Read the full methodology for the data pipeline and known limitations.

Source: ClinicalTrials.gov API v2 record for NCT06510582. Maintained by the National Library of Medicine at NIH. Public domain. Cite as: "TrialFinderData. NCT06510582. Data: ClinicalTrials.gov."

Medical disclaimer: This page is informational, not medical advice. Talk to your doctor about whether a clinical trial is right for you.

Last updated 2026-06-07 · Data from ClinicalTrials.gov.