A Pilot Study on the Effect of Cannabis Oil in Untreatable Liver Cancer Patients

Who May Qualify: - Age =\>18 yrs - Histologically proven hepatocellular carcinoma - Non-cirrhosis or Child Pugh A cirrhosis - Hepatic encephalopathy grade 0 or 1 - Multidisciplinary treatment (MDT)-advised best supportive care for untreatable advanced HCC or patients unable to undergo or declining treatment for advanced HCC. - Minimal life expectancy of 3 months - Willing and able to attend follow-up examinations - Willing to stop active traffic participation or controlling machinery during the study period if applicable - Signed willing to sign a consent form - Language: Dutch or English Who Should NOT Join This Trial: - Child Pugh B or C cirrhosis - Hepatic encephalopathy grade 2 or more - Previous systemic treatment for HCC - Mental conditions rendering the subject incapable to understand the nature, scope and consequences of the trial - Use of medicinal cannabis for other purposes - Contra-indications for medicinal cannabis oil: - Patients who have experienced a myocardial infarction or clinically significant cardiac dysfunction within the last 12 months or have had a cardiac disorder that, in the opinion of the investigator would have put the participant at risk of a clinically significant arrhythmia or myocardial infarction. - Patients with known psychotic disorders - Female patients who are pregnant or lactating - Patients (men or women) intending to start a family - Hypersensitivity to cannabinoids or any of the excipients of the cannabis oil Always talk to your doctor about whether this trial is right for you.