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RECRUITINGPhase 4INTERVENTIONAL

Statin Combined with Amlodipine Treats Primary Aldosteronism

A Prospective, Multi-center, Randomized Trial to Compare Statin Combined with CCB to MRA Combined with CCB in Primary Aldosteronism Treatment

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1: Statin combined with amlodipine besylate, scheme 2: Statin combined with Spironolactone and Amlodipine besylate. scheme 3: Amlodipine besylate combined with Spironolactone , to observe the changes in plasma aldosterone level, 24-hour urinary aldosterone, blood pressure, and long-term cardiovascular risk.

Who May Be Eligible (Plain English)

Who May Qualify: - Clinical diagnosis of primary aldosteronism Who Should NOT Join This Trial: - Allergy to drugs in this study - Pregnancy - Severe liver and kidney dysfunction - Mental illness Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Clinical diagnosis of primary aldosteronism Exclusion Criteria: * Allergy to drugs in this study * Pregnancy * Severe liver and kidney dysfunction * Mental illness

Treatments Being Tested

DRUG

Simvastatin combined with Amlodipine besylate

6-month treatment of Simvastatin combined with Amlodipine besylate

DRUG

Simvastatin combined with Spironolactone and Amlodipine besylate.

6-month treatment of Simvastatin combined with Spironolactone and Amlodipine besylate.

DRUG

Amlodipine besylate combined Spironolactone

6-month treatment of Amlodipine besylate combined with Spironolactone

Locations (1)

No. 10 Changjiang River Branch, Yuzhong District，Chongqing, China
Chongqing, Chongqing Municipality, China