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RECRUITINGOBSERVATIONAL

Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium

Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium: A Retrospective, Observational, Nationwide, Multicenter Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The objectives of this study are: (1) to describe the detailed clinical characteristics and prognosis of ASPP patients in order to explore the risk factors of ASPP, and to compare the short-term and long-term functional recovery outcomes between them and their controls; (2) to evaluate the risk of recurrent stroke, particularly during subsequent pregnancies, in ASPP patients; (3) to assess the short-term and long-term outcomes of their offsprings and their future development status. This study is divided into three parts. The first part is a case-control study to explore the risk factors of ASPP and the predictors of the prognosis of ASPP patients. The second part is a cohort study to evaluate the impact of ASPP on the risk of recurrent stroke. The third part is a cohort study to assess the impact of ASPP on the short-term and long-term outcomes of their offsprings by comparing the offsprings of ASPP patients with the offsprings of non-ASPP participants.

Who May Be Eligible (Plain English)

1\. Case-control Study and Cohort Study on Recurrent Stroke Risk: Who May Qualify: 1. Female patients ≥18 years of age; 2. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written willing to sign a consent form. Who Should NOT Join This Trial: 1. Patients or their legally acceptable representatives or relatives refuse follow-up; 2. Patients missing critical baseline demographic, clinical or neuroimaging data. 2\. Cohort Study on Offspring Outcomes: Who May Qualify: 1. Female patients ≥18 years of age; 2. Patients in pregnancy or within 6 weeks postpartum; 3. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written willing to sign a consent form. Who Should NOT Join This Trial: 1. Patients or their legally acceptable representatives or relatives refuse follow-up; 2. Patients missing critical baseline demographic, clinical or neuroimaging data; 3. Patients whose offsprings have congenital malformation or inborn error of metabolism; 4. Patients with complications which may affect cerebral blood flow supply, such as amniotic fluid embolism, in pregnancy; 5. Patients whose family members other than the parents and siblings of their offsprings have a history of severe mental illness, such as mental retardation, autism and schizophrenia; 6. Patients undergo acute myocardial infarction in pregnancy; 7. Patients undergo non-spontaneous stroke events due to other causes, such as cerebral infarction or hemorrhage caused by surgery. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
1\. Case-control Study and Cohort Study on Recurrent Stroke Risk: Inclusion Criteria: 1. Female patients ≥18 years of age; 2. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent. Exclusion Criteria: 1. Patients or their legally acceptable representatives or relatives refuse follow-up; 2. Patients missing critical baseline demographic, clinical or neuroimaging data. 2\. Cohort Study on Offspring Outcomes: Inclusion Criteria: 1. Female patients ≥18 years of age; 2. Patients in pregnancy or within 6 weeks postpartum; 3. Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent. Exclusion Criteria: 1. Patients or their legally acceptable representatives or relatives refuse follow-up; 2. Patients missing critical baseline demographic, clinical or neuroimaging data; 3. Patients whose offsprings have congenital malformation or inborn error of metabolism; 4. Patients with complications which may affect cerebral blood flow supply, such as amniotic fluid embolism, in pregnancy; 5. Patients whose family members other than the parents and siblings of their offsprings have a history of severe mental illness, such as mental retardation, autism and schizophrenia; 6. Patients undergo acute myocardial infarction in pregnancy; 7. Patients undergo non-spontaneous stroke events due to other causes, such as cerebral infarction or hemorrhage caused by surgery.

Locations (1)

Beijing Tiantan hospital
Beijing, Beijing Municipality, China