RECRUITINGPhase 4INTERVENTIONAL
Combined Anabolic Therapy
Combined Anabolic Therapy Study
About This Trial
In this research study the study investigators want to learn more about the effect of two different FDA-approved medication regimens in the treatment of postmenopausal osteoporosis.
Who May Be Eligible (Plain English)
Who May Qualify:
- women aged 45+
- postmenopausal
- osteoporotic with high risk of fracture
Who Should NOT Join This Trial:
- no significant previous use of bone health modifying treatments
- known congenital or acquired bone disease other than osteoporosis
- significant renal disease, liver disease, cardiopulmonary disease, or psychiatric disease
- abnormal calcium or parathyroid hormone level
- serum vitamin D \<20 ng/dL
- anemia (hematocrit \<32%)
- history of malignancy (except non-melanoma skin carcinoma)
- excessive alcohol use or substance abuse
- known contraindications to romosozumab or teriparatide
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* women aged 45+
* postmenopausal
* osteoporotic with high risk of fracture
Exclusion Criteria:
* no significant previous use of bone health modifying treatments
* known congenital or acquired bone disease other than osteoporosis
* significant renal disease, liver disease, cardiopulmonary disease, or psychiatric disease
* abnormal calcium or parathyroid hormone level
* serum vitamin D \<20 ng/dL
* anemia (hematocrit \<32%)
* history of malignancy (except non-melanoma skin carcinoma)
* excessive alcohol use or substance abuse
* known contraindications to romosozumab or teriparatide
Treatments Being Tested
DRUG
Romosozumab
romosozumab 210 milligrams monthly
DRUG
Teriparatide
teriparatide 20 micrograms daily
Locations (1)
Massachusetts General Hospital
Boston, Massachusetts, United States