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RECRUITINGPhase 4INTERVENTIONAL

Combined Anabolic Therapy

Combined Anabolic Therapy Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

In this research study the study investigators want to learn more about the effect of two different FDA-approved medication regimens in the treatment of postmenopausal osteoporosis.

Who May Be Eligible (Plain English)

Who May Qualify: - women aged 45+ - postmenopausal - osteoporotic with high risk of fracture Who Should NOT Join This Trial: - no significant previous use of bone health modifying treatments - known congenital or acquired bone disease other than osteoporosis - significant renal disease, liver disease, cardiopulmonary disease, or psychiatric disease - abnormal calcium or parathyroid hormone level - serum vitamin D \<20 ng/dL - anemia (hematocrit \<32%) - history of malignancy (except non-melanoma skin carcinoma) - excessive alcohol use or substance abuse - known contraindications to romosozumab or teriparatide Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * women aged 45+ * postmenopausal * osteoporotic with high risk of fracture Exclusion Criteria: * no significant previous use of bone health modifying treatments * known congenital or acquired bone disease other than osteoporosis * significant renal disease, liver disease, cardiopulmonary disease, or psychiatric disease * abnormal calcium or parathyroid hormone level * serum vitamin D \<20 ng/dL * anemia (hematocrit \<32%) * history of malignancy (except non-melanoma skin carcinoma) * excessive alcohol use or substance abuse * known contraindications to romosozumab or teriparatide

Treatments Being Tested

DRUG

Romosozumab

romosozumab 210 milligrams monthly

DRUG

Teriparatide

teriparatide 20 micrograms daily

Locations (1)

Massachusetts General Hospital
Boston, Massachusetts, United States