A Diagnostic Test to Evaluate Cancer Risk Before Surgery in Women with an Ovarian Mass

Who May Qualify: - female patients =\> 18 years of age at the time of consent - Can provide written willing to sign a consent form - Have an ovarian cyst or adnexal mass (simple, complex, or solid ovarian/pelvic mass) identified through imaging examination (e.g. transvaginal ultrasound - TVU) that requires surgery, but have not yet undergone this surgery Who Should NOT Join This Trial: - Any prior confirmed diagnosis of, or treatment for, ovarian cancer - Any prior surgery resulting in removal of both ovaries - Prior history of gynecological malignancy (within last 2 years) - Prior history of melanoma (within last 2 years) - Prior treatment (within 12 months of sample collection) with chemotherapy, radiotherapy or immunotherapy - Immune-compromised. Definition: those whose weakened immune system may render them more susceptible to infection, illness, or complications. These may include patients with immune-suppressive conditions (e.g. HIV/AIDS), patients undergoing immuno-, chemo- or radio-therapy (within the last 12 months) for any reason, receiving immune suppressive therapies (e.g. transplant recipients, individuals with known autoimmune conditions (where your immune system attacks your own body)), or with a primary weakened immune system disorder (e.g. Lupus). - Pregnant currently or within the last 3 months based on participant self-report Always talk to your doctor about whether this trial is right for you.