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RECRUITINGINTERVENTIONAL

Effect of Procyanidins in Leaky Gut Repairing in IBD

Effect of Procyanidins in the Leaky Gut Repairing Associated with Inflammatory Bowel Disease

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this clinical trial is to learn if the Grape Seed Extract Ecovitis, featuring low monomeric catechins content and a high concentration of oligo-polymeric procyanidins, could modulate the Gut Microbiota composition of Ulcerative Colitis patients during the remission phase. The main questions it aims to answer are: Does Ecovitis improve the microbiota composition in patients with Ulcerative colitis? Is the intestinal permeability affected? What about the variation in the quality of life? Participants will: Take 2 capsules/day of Ecovitis for eight weeks Visit the clinic two times for checkups, serum collection, and Questionaire.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosis of UC confirmed by clinical, endoscopic and histopathological evidence. Disease in remission phase confirmed by clinical, endoscopic and histopathological evidence. - Age between 18 and 75 years old - Ability of subject to participate fully in all aspects of this clinical trial. Who Should NOT Join This Trial: - ● Patients that have active UC, determined by clinical, endoscopic and histopathological evidences - Known diagnosis of CD, indeterminate colitis, ischemic colitis, radiation colitis, diverticular disease associated with colitis or microscopic colitis - Positive stool culture for active C. difficile - Pregnant women - Patients under antibiotic and/or probiotic treatment within 10 days prior to Visit 1. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Diagnosis of UC confirmed by clinical, endoscopic and histopathological evidence. Disease in remission phase confirmed by clinical, endoscopic and histopathological evidence. * Age between 18 and 75 years old * Ability of subject to participate fully in all aspects of this clinical trial. Exclusion Criteria: * ● Patients that have active UC, determined by clinical, endoscopic and histopathological evidences * Known diagnosis of CD, indeterminate colitis, ischemic colitis, radiation colitis, diverticular disease associated with colitis or microscopic colitis * Positive stool culture for active C. difficile * Pregnant women * Patients under antibiotic and/or probiotic treatment within 10 days prior to Visit 1.

Treatments Being Tested

BIOLOGICAL

Grape Seed Extracts

2 capsules/day for 8 weeks

Locations (1)

Edoardo Vincenzo Savarino
Padua, Padua, Italy