RECRUITINGINTERVENTIONAL

Testing the Feasibility of Computer-based Cognitive Training in Individuals with Multiple Sclerosis Living in the Community

About This Trial

Cognitive impairments are common in multiple sclerosis (MS) diagnosed both at the onset and throughout the disease course. Poor cognitive abilities have been associated with poor outcomes such as higher levels of unemployment, poor quality of life, driving difficulties among others. Learning and memory are a common cognitive deficit. This computer-based cognitive training is a 10-session treatment proven to be effective in ameliorating learning and memory in individuals with MS across 3 realms of functioning: objective cognitive performance, daily life activities and neuroimaging. Despite this strong efficacy, as well as the recent clinical application of this computer-based cognitive training across the world, recent in-person studies have highlighted that transportation to the clinic to complete treatment sessions is a significant obstacle to clinical use of this effective treatment. To address this limitation, the proposed pilot study will test the efficacy of the computer-based cognitive training administered remotely via zoom health in persons with multiple sclerosis.

Who May Be Eligible (Plain English)

Who May Qualify: - English as primary language - Diagnosis of multiple sclerosis Who Should NOT Join This Trial: - Most recent exacerbation within one month - Other Neurological History: head injury, stroke, seizures, or any other significant neurological history will not be included in the study - Individuals with an active diagnosis of Major Depressive Disorder, Schizophrenia, Bipolar Disorder I or II will be excluded from the study. - Poor Visual Acuity (corrected vision in worse eye \&lt; 20/60), diplopia, or nystagmus - Inability to understand directions and following one, two, and three step commands - Intact New Learning and Memory: Only individuals that show impaired performance on a memory test will be included in the study Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * English as primary language * Diagnosis of multiple sclerosis Exclusion Criteria: * Most recent exacerbation within one month * Other Neurological History: head injury, stroke, seizures, or any other significant neurological history will not be included in the study * Individuals with an active diagnosis of Major Depressive Disorder, Schizophrenia, Bipolar Disorder I or II will be excluded from the study. * Poor Visual Acuity (corrected vision in worse eye \&lt; 20/60), diplopia, or nystagmus * Inability to understand directions and following one, two, and three step commands * Intact New Learning and Memory: Only individuals that show impaired performance on a memory test will be included in the study

Treatments Being Tested

BEHAVIORAL

Learning and memory training

The experimental group will receive memory retraining exercises administered on a laptop computer via Zoom Health twice a week for five weeks (10 training sessions).

BEHAVIORAL

Sham Comparator

The sham comparator group will receive sham memory exercises administered on a laptop computer via Zoom Health twice a week for five weeks (10 placebo control sessions).

Locations (1)

Kessler Foundation

East Hanover, New Jersey, United States