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RECRUITINGINTERVENTIONAL

PrEP Readiness Interventions for Sustained Motivation (PRISM)

Optimizing HIV Prevention for Highly Vulnerable Methamphetamine-using Sexual Minority Men

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This is a hybrid type I, factorial randomized controlled trial to test the comparative and combined effectiveness of contingency management (CM) alone or CM with motivational interviewing (MI) for optimizing entry or re-entry into the PrEP care continuum. A total of 400 participants will be randomized to CM (n = 200) or MI+CM (n = 200), all delivered via Telehealth. Monthly follow-up assessments will be completed over 12 months to examine differential effectiveness for the primary outcome - filling a PrEP prescription (verified using a digital photo or detectable tenofovir diphosphate). Secondary outcomes will include: self-reported PrEP clinical evaluation by a PrEP provider; self-reported meth and other substance use severity (ASSIST), and self-reported receptive and insertive condomless anal sex (CAS).

Who May Be Eligible (Plain English)

Who May Qualify: - 18 years or older - Assigned male a birth - Self-reported methamphetamine use in the past 3 months - Has not filled a PrEP prescription in the past 6 months Who Should NOT Join This Trial: - Unwilling or unable to provide willing to sign a consent form Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * 18 years or older * Assigned male a birth * Self-reported methamphetamine use in the past 3 months * Has not filled a PrEP prescription in the past 6 months Exclusion Criteria: * Unwilling or unable to provide informed consent

Treatments Being Tested

BEHAVIORAL

Motivational Interviewing (MI)

This telehealth MI intervention seeks to increase intrinsic motivation and self-efficacy for starting or restarting pre-exposure prophylaxis (PrEP) in session one. Session two focuses on concomitant risk behaviors such as substance use and CAS.

BEHAVIORAL

Contingency Management (CM)

Provides incentives for initiating PrEP care ($50) and filling a PrEP prescription ($50) in the three months following randomization.

Locations (2)

Florida International University Stempel College of Public Health and Social Work
Miami, Florida, United States
Florida International University
Miami, Florida, United States