Fibrinolysis Resistance in Infection and Trauma

Sepsis/Septic shock Who May Qualify: - Admission to ICU, needing at least one organ supportand principally for the management of clinically suspected Sepsis or Septic shock according to Spesis-3 criteria (including SARS-COV-2) - Expected to remain in ICU and survive beyond the day after tomorrow Sepsis Who Should NOT Join This Trial: - On oral anticoagulant/antiplatelet therapy - Not for full, active ICU support - Death is deemed inevitable within 24 hrs Trauma Who May Qualify: - Trauma is the principal diagnosis on ICU admission - Expected to remain in ICU and survive beyond the day after tomorrow - Receiving respiratory support at the time of ICU admission - high-flow nasal prongs, non-invasive or invasive ventilation - Already received, or considered at risk of needing a blood product transfusion within 24 hrs of injury Trauma Who Should NOT Join This Trial: - Nursing home resident - Unsurvivable head injury - Not for full, active ICU support - Death is deemed inevitable within 24 hrs Always talk to your doctor about whether this trial is right for you.