Skip to main content
TTrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor.
RECRUITINGINTERVENTIONAL

Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD

A Preliminary Study on the Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of Obsessive-compulsive Disorder

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to explore the efficacy and influencing of accelerated dTMS (deep Transcranial Magnetic Stimulation) treatment in patients with obsessive-compulsive disorder (OCD), and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).

Who May Be Eligible (Plain English)

Who May Qualify: - Aged between 18 and 50, both genders are welcome. - DSM-5 criteria for OCD. - Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study. - More than 9 years of education. - Right-handed. Who Should NOT Join This Trial: - Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder. - Severe obsessive symptoms prevent the completion of necessary assessments. - Has a history of receiving ECT therapy. - Has received rTMS or tDCS treatment within the past two months. - Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others. - Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery. - Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc. - Serious suicide risk. - Pregnancy or nursing of an infant. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Aged between 18 and 50, both genders are welcome. * DSM-5 criteria for OCD. * Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study. * More than 9 years of education. * Right-handed. Exclusion Criteria: * Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder. * Severe obsessive symptoms prevent the completion of necessary assessments. * Has a history of receiving ECT therapy. * Has received rTMS or tDCS treatment within the past two months. * Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others. * Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery. * Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc. * Serious suicide risk. * Pregnancy or nursing of an infant.

Treatments Being Tested

DEVICE

Deep Transcranial Magnetic Stimulation, DTMS active

The treatment plan is to perform 2 treatments per day for 20 minutes each time, for a total of 28 treatments. Each treatment stimulates at a frequency of 20 Hz for 2 seconds, with a sequence interval of 20 seconds. Each treatment consists of 50 sequences, for a total of 2000 pulses.

DEVICE

Deep Transcranial Magnetic Stimulation, DTMS sham

The treatment plan is to perform 2 treatments per day for 20 minutes each time, for a total of 28 treatments. Compared with active treatment, the sham stimulation coil only produced sound and scalp vibration.

Locations (1)

Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China