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Effects of Primary Open-angle Glaucoma on Visual-motor Coordination

Exploring the Effects of Primary Open-Angle Glaucoma on Visual-Motor Coordination

About This Trial

Commonly used visual function assessments in glaucoma diagnosis and treatment-such as visual acuity, visual field, and contrast sensitivity-do not directly capture the impact of the disease on patients' daily abilities. While questionnaires can evaluate this impact from the patient's perspective, they are subject to individual biases and inconsistent evaluation standards. Thus, objective methods are needed to assess patients' abilities in visually guided daily activities. Grasping objects and avoiding obstacles are fundamental visually guided tasks that require effective visuomotor coordination. By attaching lightweight reflective markers to participants' limbs and using a motion capture system to track their movements in three-dimensional space, various indicators of planning, execution, and control in tasks such as object grasping and obstacle avoidance can be quantified, allowing for an objective evaluation of visuomotor coordination. However, it remains unclear how visuomotor coordination is affected in glaucoma patients at different disease stages or whether visual field damage in specific areas has distinct impacts on visuomotor coordination. This study, therefore, aims to investigate changes in visuomotor coordination among patients with primary open-angle glaucoma across disease stages and to determine the effects of visual field defects in different locations on their visuomotor abilities.

Who May Be Eligible (Plain English)

Who May Qualify: 1.1 Inclusion criteria of primary open-angle glaucoma group: 1. Age between 18 and 75 years; 2. Diagnosed with primary open-angle glaucoma, with no anti-glaucoma surgery scheduled within ±1 month; 3. Best corrected visual acuity in one eye ≥ 6/12; 4. Stereoscopic vision ≥ 1000 seconds of arc; 5. Able to clearly communicate and cooperate with the completion of relevant assessments and data collection. 1.2 Inclusion criteria of healthy controls： 1. Age between 18 and 75 years; 2. No history of eye disease other than refractive error and cataract; 3. Best corrected visual acuity in both eyes ≥ 6/12; 4. Stereoscopic vision ≥ 1000 seconds of arc; 5. Able to clearly communicate and cooperate with the completion of relevant assessments and data collection. Who Should NOT Join This Trial: 1.1 Exclusion criteria for primary open-angle glaucoma group: 1. Individuals with cognitive dysfunction, psychological dysfunction, hearing impairment, or other conditions that prevent normal communication; 2. Presence of physical motor dysfunction, hyperthyroidism or hypothyroidism, malignant tumors, heart disease, or other systemic diseases; 3. Presence of other ocular conditions affecting visual function (except cataract and refractive error), such as age-related macular degeneration, diabetic retinopathy, optic neuropathy, retinal vascular disease, etc.; 4. Pregnant or lactating women. 1.2 Exclusion criteria for healthy controls： 1. Individuals with cognitive dysfunction, psychological dysfunction, hearing impairment, or other conditions that prevent normal communication; 2. Presence of physical motor dysfunction, hyperthyroidism or hypothyroidism, malignant tumors, heart disease, or other systemic diseases; 3. Presence of other ocular conditions affecting visual function (except cataract and refractive error), such as age-related macular degeneration, diabetic retinopathy, optic neuropathy, retinal vascular disease, etc.; 4. Pregnant or lactating women. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: 1.1 Inclusion criteria of primary open-angle glaucoma group: 1. Age between 18 and 75 years; 2. Diagnosed with primary open-angle glaucoma, with no anti-glaucoma surgery scheduled within ±1 month; 3. Best corrected visual acuity in one eye ≥ 6/12; 4. Stereoscopic vision ≥ 1000 seconds of arc; 5. Able to clearly communicate and cooperate with the completion of relevant assessments and data collection. 1.2 Inclusion criteria of healthy controls： 1. Age between 18 and 75 years; 2. No history of eye disease other than refractive error and cataract; 3. Best corrected visual acuity in both eyes ≥ 6/12; 4. Stereoscopic vision ≥ 1000 seconds of arc; 5. Able to clearly communicate and cooperate with the completion of relevant assessments and data collection. Exclusion Criteria: 1.1 Exclusion criteria for primary open-angle glaucoma group: 1. Individuals with cognitive dysfunction, psychological dysfunction, hearing impairment, or other conditions that prevent normal communication; 2. Presence of physical motor dysfunction, hyperthyroidism or hypothyroidism, malignant tumors, heart disease, or other systemic diseases; 3. Presence of other ocular conditions affecting visual function (except cataract and refractive error), such as age-related macular degeneration, diabetic retinopathy, optic neuropathy, retinal vascular disease, etc.; 4. Pregnant or lactating women. 1.2 Exclusion criteria for healthy controls： 1. Individuals with cognitive dysfunction, psychological dysfunction, hearing impairment, or other conditions that prevent normal communication; 2. Presence of physical motor dysfunction, hyperthyroidism or hypothyroidism, malignant tumors, heart disease, or other systemic diseases; 3. Presence of other ocular conditions affecting visual function (except cataract and refractive error), such as age-related macular degeneration, diabetic retinopathy, optic neuropathy, retinal vascular disease, etc.; 4. Pregnant or lactating women.

Locations (1)

Zhongshan Opthalmic Center, Sun Yat-sen University

Guangzhou, Guangdong, China